Clinical and Immunological Assessment of Periodontal Disease in Japanese Leprosy Patients

DOI Web Site Web Site
  • Ohyama Hideki
    Department of Pathology, Hyogo College of Medicine, Japan
  • Hongyo Hiroshi
    National Sanatorium Kuryu-Rakusen-En, Japan
  • Shimizu Naoko
    National Sanatorium Kuryu-Rakusen-En, Japan
  • Shimizu Yoshikazu
    National Sanatorium Kuryu-Rakusen-En, Japan
  • Nishimura Fusanori
    Department of Dental Science for Health Promotion, Division of Cervico-Gnathostomatology, Hiroshima University Graduate School of Biomedical Sciences, Japan
  • Nakagawa Masatsugu
    National Sanatorium Nagashima-Aisei-En, Japan
  • Arai Hideo
    National Sanatorium Oku-Komyo-En, Japan
  • Kato-Kogoe Nahoko
    Department of Pathology, Hyogo College of Medicine, Japan
  • Terada Nobuyuki
    Department of Pathology, Hyogo College of Medicine, Japan
  • Nagai Atsushi
    Department of Odontology, Section of Periodontology, Fukuoka Dental College, Japan
  • Takashiba Shogo
    Department of Pathophysiology/Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
  • Kurihara Hidemi
    Department of Periodontal Medicine, Division of Frontier Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan
  • Nomura Yoshio
    Faculty of Oral Health, Kobe Tokiwa University, Japan
  • Murayama Yoji
    Department of Pathophysiology/Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

Search this article

Abstract

<p>Periodontitis is a chronic inflammatory disease caused by the infection of periodontopathic bacteria in dental plaque. However, an individual's susceptibility to this disease appears to be associated with multiple genetic factors, as seen in the case of leprosy. In order to gain a better understanding of the pathophysiology of periodontal disease in subjects with leprosy, we investigated the clinical features of periodontitis and the immunological responses against periodontopathic bacteria in 382 subjects with a history of leprosy and 451 age-matched control subjects. The prevalence of periodontitis and the degree of periodontal pocket depth were found to be significantly higher in leprosy patients than in age-matched controls. Furthermore, a comparison of the clinical parameters of lepromatous leprosy (L-lep) and tuberculoid leprosy (T-lep) patients showed that the probing pocket depth of L-lep patients with periodontal disease was significantly higher than that for T-lep patients. In contrast, serum IgG titers against Porphyromonas gingivalis in L-lep patients were significantly lower than in T-lep patients. These results imply that L-lep patients show more severe periodontal disease than T-lep patients or age-matched control subjects, and that low humoral immunity against P. gingivalis might be one of the genetic factors determining periodontal disease susceptibility in leprosy patients.<tt> </tt></p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 63 (6), 427-432, 2010-11-30

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top