除痛剤の合成 (第4報)

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書誌事項

タイトル別名
  • Syntheses of Analgesics. IV
  • 除痛剤の合成-4-
  • ジョツウザイ ノ ゴウセイ 4
  • アミノチクロヘキサン誘導体について その3
  • Aminocyclohexane Derivatives. (3)

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抄録

1) Application of alkylmagnesium bromides respectively to 2-diethylamino-, 2-piperidino-, and 2-morpholino-methylcyclohexanone yielded the corresponding 1-alkyl-2-diethylamino-, -2-piperidino-, and -2-morpholino-methylcyclohexanols. The latter was converted to a series of esters by condensation with aromatic acid chlorides.<br>2) Application of acetyl or isovaleryl chloride or ethyl chlorocarbonate to 2-alkyl-(or benzyl)-2-dimethylaminomethylcyclohexanols yielded the corresponding esters.<br>3) Application of ethyl chlorocarbonate respectively to 1-alkyl-1-p-aminobenzoyloxy-2-dimethyl (or diethyl) aminomethylcyclohexanes gave the urethanes. β-Bromopropionyl ester was obtained by the application of β-bromopropionyl chloride to 1-ethyl-2-dimethyl-aminomethylcyclohexanol and condensation of dimethylamine to the ester yielded 1-β-dimethylaminopropionyloxy derivative.

収録刊行物

  • 薬学雑誌

    薬学雑誌 74 (11), 1141-1144, 1954

    公益社団法人 日本薬学会

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