The study of the origin and subdifferentiation of the malignant lymphoma diffuse large B-cell lymphoma

DOI Web Site

Bibliographic Information

Other Title
  • 悪性リンパ腫びまん性大細胞型Bリンパ腫(Diffuse large B-cell lymphoma)の発生母地と亜分類に関する検討
  • アクセイ リンパ シュビマンセイ ダイ サイボウガタ Bリンパ シュ Diffuse large B cell lymphoma ノ ハッ セイボチ ト アブンルイ ニ カンスル ケントウ

Search this article

Abstract

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of malignant lymphoma, is clinically and pathologicaly heterogeneous.We studied 104 cases of DLBCL with the method that Hans and coworkers developed an immunohistochemical algorithm using CD10, BCL-6 and MUM-1. 24 (23%) cases were considered germinal center B cel l type (GCB type) which expressed CD10 or BCL-6, another 80 (77%) cases were non germinal center B cell type (Non GCB type) which expressed BCL-6 or MUM-1. The tumor cells of GCB type were centroblastic or centrocytic cells, and these of Non GCB type were immunoblastic and plasmacitic cells. Fortermore we studied malignancy using Ki-67 and mitotic index. Conclusively we found no difference in malignancy between the GCB type and non GCB type groups. A immunohistochemistry woud have wide applicability and practical utility in routine clinical practice.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top