Molecular Epidemiology of Human Rhinovirus C in Patients with Acute Respiratory Tract Infections in Osaka City, Japan

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  • Kaida Atsushi
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Japan
  • Kubo Hideyuki
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Japan
  • Takakura Koh-Ichi
    Department of Urban Environment, Osaka City Institute of Public Health and Environmental Sciences, Japan
  • Togawa Masao
    Osaka City Sumiyoshi Hospital, Japan
  • Shiomi Masashi
    Osaka City General Hospital, Japan
  • Kohdera Urara
    Nakano Children’s Hospital, Japan
  • Iritani Nobuhiro
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Japan

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Abstract

<p>Human rhinovirus (HRV) is a causative agent of acute respiratory tract infection (ARTI). In 2007, a novel HRV group, HRV-C, was discovered. This study, which assessed whether HRV-C is epidemic among patients with ARTI, was aimed at analyzing the seasonal prevalence of HRV-C in Osaka City, Japan. Gene amplification tests were performed to detect 10 respiratory viruses in 336 specimens collected during November 2008–October 2009. In total, 364 viruses were detected in 271 specimens. The most commonly detected virus was HRV (n = 84). For HRV-positive specimens, we conducted phylogenetic analyses using the VP4/VP2 gene region to identify the HRV species (HRV-C, 30; HRV-A, 54). Both the number and rate of HRV-C detection were highest in December. The highest numbers and the highest rate of HRV-A detection were obtained in April and June and in April, respectively. Statistical analysis showed that the most probable prevalent period of HRV-C was between September and March, and that of HRV-A was between March and November. These results suggest that HRV-C is mainly epidemic during autumn and early spring; this seasonal prevalence was different from that of HRV-A. Moreover, the HRV-C Osaka strains were scattered in many genetic clusters along with previously reported strains from different parts of the world. This result also emphasizes the worldwide circulation of HRV-C.<tt> </tt></p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 64 (6), 488-492, 2011-11-30

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

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