Grevillosides J–Q, Arbutin Derivatives from the Leaves of Grevillea robusta and Their Melanogenesis Inhibitory Activity

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  • Yamashita-Higuchi Yukiko
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Sugimoto Sachiko
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Matsunami Katsuyoshi
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Otsuka Hideaki
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women’s University
  • Nakai Takahito
    Kashiwara R&D Center, Nihon Kolmar Co., Ltd.

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  • Grevillosides J–Q, Arbutin Derivatives from the Leaves of <i>Grevillea robusta</i> and Their Melanogenesis Inhibitory Activity

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From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Grevillea robusta, new arbutin derivatives and related compounds, named grevillosides J–Q (1–8), together with eight known compounds (9–18) were isolated. Various kind of acyl groups were attached to β-D-glucose at the 6-position through an ester linkage. Their structures were mainly elucidated from one- and two-dimensional NMR spectroscopic data. For exploitation as skin-lightening and anti-chloasma agents, the inhibitory activities of the isolated compounds as well as ones isolated in previous experiments (19–31) toward tyrosinase and melanin-producing B16 cells were assayed. Several compounds showed promising activity.

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