Effects of Supplemental β-Cryptoxanthin on IgA-secreting Cells in the Intestine and Mammary Glands of Lactating Mice

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<p>The present study was conducted to clarify the effects of supplemental β-cryptoxanthin in maternal mice during pregnancy and lactation on IgA antibody-secreting cells (ASC) in the intestine and mammary glands of lactating mice. From 6.5 days postcoitus to 7 or 14 days postpartum (dpp), maternal mice were fed rodent feed or 50 mg/kg β-cryptoxanthin-supplemented rodent feed. Supplemental β-cryptoxanthin increased the numbers of IgA ASC and the mRNA expressions of IgA C-region, CCL25 and CCL28 in the jejunum at 14 dpp. Supplemental β-cryptoxanthin had no effects on the numbers of IgA ASC in the ileum and mammary glands, although supplemental β-cryptoxanthin increased the mRNA expression of IgA C-region in the ileum and mammary glands at 14 dpp. Supplemental β -cryptoxanthin had no effects on IgA concentrations in serum, stomach contents, intestines and feces of neonatal mice. These results imply that supplemental β-cryptoxanthin in maternal mice during pregnancy and lactation is effective to increase the numbers of IgA ASC in the jejunum during late lactation.</p>

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