Characterization of an anti-varicella-zoster virus compound that targets the portal protein encoded by ORF54

• Ruka Yasui

• Chinatsu Yoshida

• Toyofumi Yamaguchi

• Naoki Inoue

Abstract

<jats:label /> An anti‐varicella‐zoster virus compound, a 5‐chlorobenzo[b]thiophen derivative (45B5), was characterized. Its 50% effective concentration against the cell‐free vaccine Oka strain and 50% cytotoxic concentration in human fibroblasts were 16.9 µM and more than 100 µM, respectively. Treatment with 45B5 decreased viral DNA synthesis and IE62 expression weakly but significantly. All 45B5‐resistant viral clones isolated were found to have at least one mutation in ORF54 that encodes the portal protein. There were no effects on interaction between the portal and scaffold proteins. Thus, 45B5 may inhibit nuclear delivery of viral DNA.

Journal

• Microbiology and immunology / Japanese Society for Bacteriology, Japanese Society for Virology, Japanese Society for Host Defense Research

  Microbiology and immunology / Japanese Society for Bacteriology, Japanese Society for Virology, Japanese Society for Host Defense Research 61 (9), 398-402, 2017-09

  Richmond : Blackwell Publishing Asia Pty

Keywords

• antiviral compound
• capsid
• portal protein
• varicella-zoster virus

Details

• CRID: 1520291855131391616
• NII Article ID: 40021326058
• NII Book ID: AA00738350
• ISSN: 03855600
• ISSN: 13480421
• DOI: 10.1111/1348-0421.12507
• NDL BIB ID: 028530884
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028530884
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1348-0421.12507
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/1348-0421.12507
• Web Site: https://search.jamas.or.jp/link/ui/2018227313
• Text Lang: en
• NDL Source Classification:
  • ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
• Data Source:
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN