Acute effect of ivabradine on heart rate and myocardial oxygen consumption in          dogs with asymptomatic mitral valve degeneration

Pirintr Prapawadee, Limprasutr Vudhiporn, Saengklub Nakkawee, Pavinadol Parnpradub, Yapao Napat, Limvanicharat Natthakarn, Kuecharoen Hathaisiri, Kijtawornrat Anusak

doi:10.1538/expanim.18-0030

<p>Degenerative mitral valve disease (DMVD) is a common cardiac disease in geriatric dogs characterized by the degeneration of the mitral valve, leading to decreased cardiac output and activation of the sympathetic and renin-angiotensin-aldosterone system. This disease results in an increased resting heart rate (HR) and myocardial oxygen consumption (MVO₂). A recent publication demonstrated that dogs with asymptomatic DMVD had a significantly higher HR and systemic blood pressure (BP) than age-matched control dogs. This higher HR will eventually contribute to increased MVO₂. This study aimed to determine the effects of a single oral dose of ivabradine on the HR, MVO₂ as assessed by the rate-pressure product, and BP in dogs with asymptomatic DMVD. Seven beagles with naturally occurring DMVD were instrumented by the Holter recorder and an oscillometric device to measure electrocardiogram and BP for 24 and 12 h, respectively. Each dog was randomly subjected to receive either placebo or ivabradine (0.5, 1.0 and 2.0 mg/kg). The results revealed that oral administration of ivabradine significantly decreased the HR and rate-pressure product in a dose-dependent manner without adverse effects. The highest dose of 2.0 mg/kg significantly reduced systolic and mean BP. Therefore, the findings imply that a single oral ivabradine administration at a dose of 1.0 mg/kg is suitable for dogs with asymptomatic DMVD to reduce the HR and MVO₂ without marked effects on BP. This may potentially make ivabradine promising for management of an elevated HR in DMVD dogs.</p>

Acute effect of ivabradine on heart rate and myocardial oxygen consumption in dogs with asymptomatic mitral valve degeneration

この論文をさがす

抄録

収録刊行物

参考文献 (28)*注記

キーワード

詳細情報詳細情報について

書き出し

問題の指摘