亜セレン酸またはセレノメチオニンの栄養有効性に及ぼす投与期間の影響

DOI Web Site
  • 廣瀬 侑太郎
    関西大学化学生命工学部栄養化学・食品化学研究室
  • 北川 怜子
    関西大学化学生命工学部栄養化学・食品化学研究室
  • 下川 真由子
    関西大学化学生命工学部栄養化学・食品化学研究室
  • 細見 亮太
    関西大学化学生命工学部栄養化学・食品化学研究室
  • 福永 賢治
    関西大学化学生命工学部栄養化学・食品化学研究室
  • 吉田 宗弘
    関西大学化学生命工学部栄養化学・食品化学研究室

書誌事項

タイトル別名
  • Effect of Administration Period on Nutritional Availability of Selenite or Selenomethionine in Rats
  • アセレンサン マタワ セレノメチオニン ノ エイヨウ ユウコウセイ ニ オヨボス トウヨ キカン ノ エイキョウ

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抄録

<p>To examine an effect of administration period on nutritional availability of selenite or selenomethionine (SeM) as selenium (Se) source, both Se compounds were administered to rats with a low-Se state for 1 or 4 weeks and measured tissue Se content and glutathione peroxidase (GPX) activity. Male 4-week Wistar rats were fed a casein-based low Se basal diet (Se content, 0.061 mg/kg) for 3 weeks and then divided into three groups. One group was fed the low-Se basal diet continuously and other two groups were fed the basal diet supplemented with Se (0.2 mg/kg) as sodium selenite or l-SeM for further 1 or 4 weeks. Dietary Se-supplementation caused an increase of Se content and GPX activity in the serum, liver and kidney. Effect of selenite exceeded that of SeM in the kidney Se, liver GPX and kidney GPX after the 1-week supplementation. After the 4-week supplementation, effect of SeM exceeded that of selenite in the liver Se and the difference among Se compounds in the liver and kidney GPX observed in the 1-week supplementation disappeared. The serum GPX was not increased by the 1-week Se supplementation and was increased only by the selenite-supplementation for 4 weeks. These results indicate that a nutritional availability of selenite exceeds that of SeM at a short-term administration but the availability of SeM becomes to be comparable to that of selenite at a long-term administration.</p>

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