Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men　― The Japan Public Health Center-Based Prospective Study Cohort II ―

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  • Hayashi Rie
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Iso Hiroyasu
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba
  • Yamagishi Kazumasa
    Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba
  • Yatsuya Hiroshi
    Department of Public Health, Fujita Health University, School of Medicine
  • Saito Isao
    Department of Community Health Systems Nursing, Ehime University Graduate School of Medicine
  • Kokubo Yoshihiro
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center
  • Eshak Ehab S.
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health and Preventive Medicine, Faculty of Medicine Minia University
  • Sawada Norie
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
  • Tsugane Shoichiro
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
  • for the Japan Public Health Center-Based (JPHC) Prospective Study Group

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<p>Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited </p><p>Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40–59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01–2.63) for acute myocardial infarction and 0.83 (95% CI 0.60–1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03–4.35) and men aged 50–59 years (HR 2.60, 95% CI 1.42–4.77). </p><p>Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction. </p>

収録刊行物

  • Circulation Journal

    Circulation Journal 83 (5), 1072-1079, 2019-04-25

    一般社団法人 日本循環器学会

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