Age-Related Differences in the Clinical Characteristics and Treatment of Elderly Patients With Atrial Fibrillation in Japan ― Insight From the ANAFIE (All Nippon AF In Elderly) Registry ―
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- Hiasa Ken-ichi
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
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- Kaku Hidetaka
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
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- Inoue Hiroshi
- Saiseikai Toyama Hospital
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- Yamashita Takeshi
- The Cardiovascular Research Institute
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- Akao Masaharu
- National Hospital Organization Kyoto Medical Center
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- Atarashi Hirotsugu
- Minami Hachioji Hospital
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- Koretsune Yukihiro
- National Hospital Organization Osaka National Hospital
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- Okumura Ken
- Saiseikai Kumamoto Hospital
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- Shimizu Wataru
- Nippon Medical School
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- Ikeda Takanori
- Toho University Omori Medical Center
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- Toyoda Kazunori
- National Cerebral and Cardiovascular Research Center Hospital
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- Hirayama Atsushi
- Osaka Police Hospital
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- Yasaka Masahiro
- National Hospital Organization Kyushu Medical Center
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- Yamaguchi Takenori
- National Cerebral and Cardiovascular Research Center Hospital
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- Teramukai Satoshi
- Kyoto Prefectural University of Medicine
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- Kimura Tetsuya
- Medical Science Department, Daiichi Sankyo Co., Ltd.
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- Kaburagi Jumpei
- Medical Science Department, Daiichi Sankyo Co., Ltd.
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- Takita Atsushi
- Biostatistics and Data Management Department, Daiichi Sankyo Co., Ltd.
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- Tsutsui Hiroyuki
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
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抄録
<p>Background:Atrial fibrillation (AF) is increasing as the global population ages. Elderly AF patients (≥75 years) have a worse prognosis than younger patients, and effective management is often difficult due to multiple comorbidities. This analysis examined the age-related differences in clinical characteristics and treatment in real-world elderly Japanese AF patients.</p><p>Methods and Results:The ANAFIE Registry is a multicenter, prospective, observational registry of 32,726 non-valvular AF patients aged ≥75 years. The present study assessed the age-related differences in baseline clinical status and anticoagulant therapy between age groups 75–<80, 80–<85, 85–<90, and ≥90 years. The prevalence of persistent or permanent AF increased, and that of paroxysmal AF decreased, with increasing age (trend P<0.0001). The risk of stroke, based on CHADS2and CHA2DS2-VASc scores, and bleeding, based on HAS-BLED score, increased with age. Both warfarin and apixaban were used more often as age increased (trend P<0.0001, for each), while other anticoagulants were used less. Anticoagulant doses were significantly lower in older patients.</p><p>Conclusions:Permanent/persistent AF, comorbidities, and cardiovascular and bleeding risk all increased significantly with age. Furthermore, use of warfarin and apixaban increased with age, accompanied by a decrease in other oral anticoagulant usage.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 84 (3), 388-396, 2020-02-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390283659853923968
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- NII論文ID
- 130007801772
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 030281759
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- PubMed
- 31969518
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可