Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease

• Miyata Masaaki

  Department of Food Science and Technology, National Research and Development Agency, Japan Fisheries Research and Education Agency, National Fisheries University

• Funaki Akihiro

  Department of Food Science and Technology, National Research and Development Agency, Japan Fisheries Research and Education Agency, National Fisheries University

• Fukuhara Chiaki

  Department of Food Science and Technology, National Research and Development Agency, Japan Fisheries Research and Education Agency, National Fisheries University

• Sumiya Yukino

  Department of Food Science and Technology, National Research and Development Agency, Japan Fisheries Research and Education Agency, National Fisheries University

• Sugiura Yoshimasa

  Department of Food Science and Technology, National Research and Development Agency, Japan Fisheries Research and Education Agency, National Fisheries University

抄録

Mice lacking the farnesoid X receptor (FXR) are used as a genetic model for nonalcoholic fatty liver disease because their livers exhibit hepatic steatosis and inflammation. The influence of taurine drinking on disrupted hepatic function was investigated using female Fxr-null mice. Significant decreases in the levels of hepatic damage-associated diagnostic markers, hepatic triglycerides, non-esterified fatty acids, and total bile acids were found in Fxr-null mice that had drunk water containing 0.5% taurine for four weeks. Hepatic but not serum taurine concentrations were significantly increased in these mice. The expression levels of oxidative stress-related genes (Hmox1 and Gsta1) and fatty acid synthetic genes (Acc1 and Scd1) were significantly decreased in these mice. These results suggest that drinking taurine improves hepatic steatosis and dysfunction caused by a lack of FXR.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 45 (2), 87-94, 2020

  一般社団法人　日本毒性学会

キーワード

• Taurine
• FXR
• Steatosis
• NAFLD

詳細情報

• CRID: 1390565134828933248
• NII論文ID: 130007798444
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.45.87
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 030384433
• PubMed: 32062620
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030384433
• Web Site: https://www.jstage.jst.go.jp/article/jts/45/2/45_87/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021042663
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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