好熱性細菌および酵母菌による多段階培養発酵技術から得られた発酵エキスの皮膚に対する有用性

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  • Efficacy of Fermented Extract Obtained from Multiple-Processed Fermentation Technology of Thermophilic Bacteria and Yeast
  • コウネッセイ サイキン オヨビ コウボキン ニ ヨル タダンカイ バイヨウ ハッコウ ギジュツ カラ エラレタ ハッコウ エキス ノ ヒフ ニ タイスル ユウヨウセイ

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<p>Demand for natural ingredients is growing in cosmetic industry, and Saccharomyces cerevisiae extract is one of the most common natural ingredients. We have conducted the functional evaluation of Multiple-Processed Fermentation Extract (MPFE), Thermus thermophilus and Saccharomyces cerevisiae, the conventional technology in food industry, via our original fermentation process. Our results show that the MPFE exhibits several skin benefits such as recovery, anti-inflammation, moisturization etc. based on gene expression analysis. Furthermore, it demonstrated equal or even higher anti-inflammation benefit compared with dexamethasone, the steroidal anti-inflammatory drug, based on the significant decrease of the inflammatory marker analysis. MPFE also demonstrated higher cell proliferation and skin barrier repair compared with either Thermus thermophilus or Saccharomyces cerevisiae, respectively. In terms of macrophage activation, MPFE showed higher activation than lipopolysaccharide (LPS), the well-known macrophage activator.</p><p>The combination of Thermus thermophilus and Saccharomyces cerevisiae demonstrated strong synergy in terms of skin cell proliferation, anti-inflammation, macrophage activation and skin barrier repair compared with either Thermus thermophilus or Saccharomyces cerevisiae, respectively, thereby suggesting the better skin benefits than each individual ingredient.This evaluation method provides a new approach to study the skin benefits for the combination of multi fermented extracts.</p>

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