Two Cu(II) and Co(II) Coordination Polymers: Important Values on Colon Cancer Patients by Reducing Insulin Resistance
-
- Cao Xiang
- Department of Gastrointestinal Surgery, Changzhou No.2 People’s Hospital Affiliated to Nanjing Medical University
-
- Zhu Ping
- Department of Gastrointestinal Surgery, Changzhou No.2 People’s Hospital Affiliated to Nanjing Medical University
-
- Zhu Qiu-Wei
- Department of Gastrointestinal Surgery, Changzhou No.2 People’s Hospital Affiliated to Nanjing Medical University
-
- Shi Jun
- Department of Gastrointestinal Surgery, Changzhou No.2 People’s Hospital Affiliated to Nanjing Medical University
-
- Li Dong
- Department of Chemistry, Nanchang University
-
- Cui Jili
- Department of Chemistry, Nanchang University
この論文をさがす
抄録
<p>In the current study, via utilizing H5L (H5L = 2,4-di(3′,5′-dicarboxylphenyl)benzoic acid), the symmetrical rigid polycarboxylic acid ligand with V-shape geometry, two new coordination polymers containing Cu(II) and Co(II) have been produced, and their chemical formulae respectively are {[Co5(L)2(H2O)12]·6H2O} n (1) and {[H2N(Me)2][Cu2(L)(H2O)]·DMF·H2O} n (2), leading to a variety kinds of coordination patterns of H5L and multifunctional skeletons. Their inhibitory activity on the insulin resistance of colon cancer patients was assessed. In addition, the detailed mechanism of the compound was also investigated. Firstly, the detection of enzyme-linked immunosorbent assay was carried out and the Tumor Necrosis Factor-α (TNF-α) level and the Interleukin-1β (IL-1β) level was detected. Then, the glucose concentration was determined with blood glucose meter. Next, the insulin receptor expression levels of β cells were determined with the real time reverse transcription-polymerase chain reaction assay. Ultimately, the cytotoxicity of compounds 1 and 2 was determined with Cell Counting Kit-8 assay.</p>
収録刊行物
-
- Journal of Oleo Science
-
Journal of Oleo Science 70 (6), 827-835, 2021
公益社団法人 日本油化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390569690547398144
-
- NII論文ID
- 130008046367
-
- NII書誌ID
- AA11503337
-
- ISSN
- 13473352
- 13458957
-
- NDL書誌ID
- 031467861
-
- PubMed
- 34078759
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可