Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
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<jats:title>Abstract</jats:title><jats:p>Nature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has gradually become more challenging, and advances in novel strategic approaches are essential to evolve natural product chemistry. Our focus has been on surveying untouched marine resources and fermentation to enhance microbial productive performance. The first topic is the screening of marine natural products isolated from Indonesian marine organisms for new types of bioactive compounds, such as antineoplastics, antimycobacterium substances, and inhibitors of protein tyrosine phosphatase 1B, sterol <jats:italic>O</jats:italic>-acyl-transferase, and bone morphogenetic protein-induced osteoblastic differentiation. The unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented. This review presents an overview of our recent work accomplishments based on the MONOTORI study.</jats:p> <jats:p><jats:bold>Graphic abstract</jats:bold></jats:p>
収録刊行物
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- Journal of natural medicines / The Japanese Society of Pharmacognosy
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Journal of natural medicines / The Japanese Society of Pharmacognosy 76 (1), 1-19, 2022
Tokyo : Springer Japan Production Department
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詳細情報 詳細情報について
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- CRID
- 1522825131105930240
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- NII論文ID
- 40022799474
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- NII書誌ID
- AA12114658
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- ISSN
- 13403443
- 18610293
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- NDL書誌ID
- 031931365
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZS51(科学技術--薬学)
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- データソース種別
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- NDL
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