Studies on expedient functionalization in cephalosporin antibiotic synthesis セファロスポリン系抗生物質合成における特異的官能基変換に関する研究
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著者
書誌事項
- タイトル
-
Studies on expedient functionalization in cephalosporin antibiotic synthesis
- タイトル別名
-
セファロスポリン系抗生物質合成における特異的官能基変換に関する研究
- 著者名
-
谷口, 正俊
- 著者別名
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タニグチ, マサトシ
- 学位授与大学
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岡山大学
- 取得学位
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工学博士
- 学位授与番号
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甲第926号
- 学位授与年月日
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1991-03-28
注記・抄録
博士論文
目次
- Table of Contents / (0003.jp2)
- Chapter 1.Introduction and General Summary / p1 (0004.jp2)
- Chapter 2.Phenonium Ion-Promoted Deprotection of Esters of β-Lactam Derivatives / p29 (0018.jp2)
- 2.1 Deprotection of 7-Phenylacetamido-3-(l-methyl- l,2,3,4-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylates / p32 (0020.jp2)
- 2.2 Deprotection of Various β-Lactam Carboxylates / p41 (0024.jp2)
- 2.3 Experimental Section / p46 (0027.jp2)
- Chapter 3.A Facile Synthesis of 4-(Phenylsulfonylthio)azetidin-2-ones / p61 (0034.jp2)
- 3.1 A Facile Synthesis of 2-Benzothiazolyl benzenethio-sulfonates by Electrolytic Cross-Coupling Reaction / p67 (0037.jp2)
- 3.2 A Convenient Synthesis of 4-(Phenylsulfonylthio)-azetidin-2-ones by the Reaction of 4-(2-Benzothia-zolylthio)azetidin-2-ones with 2-Benzothiazolyl benzenethiosulfonates / p72 (0040.jp2)
- 3.3 Experimental Section / p76 (0042.jp2)
- Chapter 4.A Synthesis of 3-Hydroxy-3-cephems by Bi/Sn Bimetal Redox-Promoted Cyclization of 4-(Phenylsulfonylthio)-azetidin-2-ones / p83 (0045.jp2)
- 4.1 C=C Bond Fission of Chlorinated 4-(Phenylsulfonylthio)-azetidin-2-ones 5 / p88 (0048.jp2)
- 4.2 Cyclization of Enol 6 to 3-Hydroxy-3-cephems 1 / p91 (0049.jp2)
- 4.3 Cyclization of Protected Enol 8 / p94 (0051.jp2)
- 4.4 Mechanism of the Reductive Cyclization of 6 / p96 (0052.jp2)
- 4.5 Experimental Section / p98 (0053.jp2)
- Chapter 5. A Facile Synthesis to 3-Formyl-3-cephems from 3-Iodomethyl-3-cephems by Oxidation with Dioxygen / p111 (0059.jp2)
- 5.1 Dioxygen or Air-Oxidation of 3-Iodomethyl-3-cephems / p116 (0062.jp2)
- 5.2 Experimental Section / p119 (0063.jp2)
- Chapter 6. A Facile Synthesis of Thiazoline-Azetidin-2-ones Through Electrolytic Removal of N-Substituent Moieties on β-Lactam / p123 (0065.jp2)
- 6.1 Electrolytic Removal of N-Substituent Moieties on β-Lactam / p127 (0067.jp2)
- 6.2 Experimental Section / p131 (0069.jp2)
- Publication List / p137 (0072.jp2)
- Acknowledgement / p142 (0075.jp2)