Mechanisms of catecholamine-induced relaxation in smooth muscle カテコラミンの平滑筋弛緩作用
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著者
書誌事項
- タイトル
-
Mechanisms of catecholamine-induced relaxation in smooth muscle
- タイトル別名
-
カテコラミンの平滑筋弛緩作用
- 著者名
-
權, 成春
- 著者別名
-
ゴン, ソンチュン
- 学位授与大学
-
東京大学
- 取得学位
-
農学博士
- 学位授与番号
-
甲第9140号
- 学位授与年月日
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1991-03-29
注記・抄録
博士論文
目次
- CONTENTS / (0003.jp2)
- I.Introduction / p1 (0007.jp2)
- 1.Catecholamines / p1 (0007.jp2)
- 1-1.Synthesis / p1 (0007.jp2)
- 1-2.Storage,release and metabolism / p2 (0008.jp2)
- 1-3.Adrenergic receptors / p3 (0009.jp2)
- 2.Catecholamine action / p4 (0010.jp2)
- 2-1.Contraction and relaxation / p4 (0010.jp2)
- 2-2.Catecholamine-mediated contraction and relaxation / p5 (0011.jp2)
- 3.Cyclic nucleotides / p7 (0013.jp2)
- 3-1.cAMP / p7 (0013.jp2)
- 3-2.cGMP / p8 (0014.jp2)
- 4.Purpose of the present experiments / p8 (0014.jp2)
- II.MATERIALS and METHODS / p10 (0016.jp2)
- 1.Tissue preparations and solutions / p10 (0016.jp2)
- 2.Measurement of muscle tension / p11 (0017.jp2)
- 3.Fura-2 loading and simultaneous measurements of muscle tension and〔Ca²⁺〕cyt / p11 (0017.jp2)
- 4.Preparation of permeabilized muscle / p12 (0018.jp2)
- 5.Measurement of tissue cyclic AMP and cyclic GMP content / p13 (0019.jp2)
- 6.Chemicals / p13 (0019.jp2)
- 7.Statistics / p14 (0020.jp2)
- III.RESULTS / p15 (0021.jp2)
- 1.The effects of catecholamines in the intestinal smooth muscles / p15 (0021.jp2)
- 1-1.Contractile tension / p15 (0021.jp2)
- 1-2.Cytosolic Ca²⁺ level / p23 (0029.jp2)
- 1-3.〔Ca²⁺〕cyt-tension relationship / p46 (0052.jp2)
- 1-4.Caffeine-induced contraction / p50 (0056.jp2)
- 1-5.Contraction induced by ouabain and 142.3 mM K⁺/0 mM Na⁺ solution / p54 (0060.jp2)
- 1-6.Contraction of permeabilized taenia coli / p54 (0060.jp2)
- 1-7.Cyclic nucleotides contents / p57 (0063.jp2)
- 2.Rat aorta / p57 (0063.jp2)
- 2-1.Contractile tension / p57 (0063.jp2)
- 2-2.Cytosolic Ca²⁺ level / p60 (0066.jp2)
- 3.Bovine trachea / p62 (0068.jp2)
- 3-1.Contractile tension / p62 (0068.jp2)
- 3-2.Cytosolic Ca²⁺ level / p65 (0071.jp2)
- 3-3.〔Ca²⁺〕cyt-tension relationship / p67 (0073.jp2)
- 4.Forskolin and sodium nitroprusside / p71 (0077.jp2)
- 4-1.Contractile tension / p71 (0077.jp2)
- 4-2.Cytosolic Ca²⁺ level / p77 (0083.jp2)
- 4-3.〔Ca²⁺〕cyt-tension relationship / p83 (0089.jp2)
- 4-4.Contraction of permeabilized taenia coli / p87 (0093.jp2)
- 4-5.Cyclic nucleotides contents / p91 (0097.jp2)
- IV.DISCUSSION / p93 (0099.jp2)
- 1.Catecholamines action in smooth muscle / p93 (0099.jp2)
- 1-1.Effect of α₁-adrenoceptor stimulation / p93 (0099.jp2)
- 1-2.Effect of α₂-adrenoceptor stimulation / p98 (0104.jp2)
- 1-3.Effect of β-adrenoceptor stimulation / p99 (0105.jp2)
- 2.Forskolin and sodium nitroprusside in intestinal smooth muscle / p104 (0110.jp2)
- 2-1.Taenia and ileum / p104 (0110.jp2)
- 2-2.Summary / p107 (0113.jp2)
- 2-3.Comparison of the effects of catecholamines with those of forskolin and sodium nitroprusside / p108 (0114.jp2)
- V.SUMMARY / p109 (0115.jp2)
- VI.REFERENCES / p113 (0119.jp2)