Studis on antifungal antibiotics tautomycin and tautomycetin 新規抗真菌抗生物質トウトマイシン及びトウトマイセチンに関する研究

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Author

    • 成, 杏春 チョン, シンチュン

Bibliographic Information

Title

Studis on antifungal antibiotics tautomycin and tautomycetin

Other Title

新規抗真菌抗生物質トウトマイシン及びトウトマイセチンに関する研究

Author

成, 杏春

Author(Another name)

チョン, シンチュン

University

東京大学

Types of degree

農学博士

Grant ID

乙第9855号

Degree year

1990-10-08

Note and Description

博士論文

Table of Contents

  1. 論文の内容の要旨 / p1 (0001.jp2)
  2. CONTENTS / p5 (0010.jp2)
  3. PREFACE / p2 (0007.jp2)
  4. PART I.Biology and Chemistry of Tautomycin(TM) / p8 (0013.jp2)
  5. Chapter1.TM-producing microorganism / p8 (0013.jp2)
  6. Chapter2.Isolation and physico-chemical properties of TM / p11 (0016.jp2)
  7. Chapter3.Biological activity of TM / p22 (0027.jp2)
  8. 3-1.MIC of TM / p22 (0027.jp2)
  9. 3-2.Activities against Sclerotinia sclerotiolum and cucumber gray mold / p23 (0028.jp2)
  10. 3-3.Induction of morphological change of human myeloid leukemia / p26 (0031.jp2)
  11. 3-4.Toxicity / p27 (0032.jp2)
  12. Chapter4.Structural elucidation of TM / p28 (0033.jp2)
  13. 4-1.Partial structure of TM / p28 (0033.jp2)
  14. 4-2.General approach for structure elucidation of TM / p37 (0042.jp2)
  15. 4-3.Hydrolysis of TM at pH 9 / p40 (0045.jp2)
  16. 4-4.Acetylation of TM-2 / p45 (0050.jp2)
  17. 4-5.Retrol-aldol cleavage of TM-2 / p50 (0055.jp2)
  18. 4-6.Ozonolysis of TM-2a / p67 (0072.jp2)
  19. 4-7.Monomethyl ester and trimethyl esters of TM-3 / p72 (0077.jp2)
  20. 4-8.2,3-Dialkylmaleic anhydride moiety and equilibrium / p87 (0092.jp2)
  21. 4-9.Total NMR assignment of TM / p92 (0097.jp2)
  22. PART II.Biology and Chemistry of Tautomycetin(TMT) / (0099.jp2)
  23. Chapterl.TMT-producing microorganism / p94 (0100.jp2)
  24. Chapter2.Isolation and physico-chemical properties of TMT / p97 (0103.jp2)
  25. Chapter3.Biological activity of TMT / p109 (0115.jp2)
  26. 3-1.MIC of TMT / p109 (0115.jp2)
  27. 3-2.Activities against Sclerotinia sclerotiolum and cucumber gray mold / p110 (0116.jp2)
  28. 3-3.Induction of morphological change of human myeloid leukemia / p111 (0117.jp2)
  29. 3-4.Toxicity / p111 (0117.jp2)
  30. Chapter4.structural elucidation of TMT / p112 (0118.jp2)
  31. 4-1.Degradation of TMT / p112 (0118.jp2)
  32. 4-2.Hydrolysis of TMT / p113 (0119.jp2)
  33. 4-3.Acetylation of TMT-2 / p118 (0124.jp2)
  34. 4-4.Monomethyl ester and trimethyl ester of TMT-3 / p131 (0137.jp2)
  35. 4-5.Total NMR assignment of TMT / p136 (0142.jp2)
  36. PART III.Biosynthesis of TM and TMT / p138 (0144.jp2)
  37. Chapter1.Biosynthesis of TM / p138 (0144.jp2)
  38. Chapter2.Biosynthesis of TMT / p157 (0163.jp2)
  39. PART IV.stereochemistry of TM / p173 (0179.jp2)
  40. Chapter1.Absolute configuration of C-3'at TM / p174 (0180.jp2)
  41. Chapter2.Relative configurations of spiroketal moiety of TM / p177 (0183.jp2)
  42. Chapter3.Relative configuration of C-22,C-23 and C-24 of TM / p184 (0190.jp2)
  43. PART V.Discussion / p190 (0196.jp2)
  44. PART VI.Experimental / p195 (0201.jp2)
  45. Chapter1.General procedure / p195 (0201.jp2)
  46. Chapter2.Preparation of TM and related degradation compounds / p197 (0203.jp2)
  47. Chapter3.Preparation of TMT and related degradation compounds / p207 (0213.jp2)
  48. Chapter4.Preparation of 〔¹³C〕and〔¹⁴C〕labeled TM and TMT / p212 (0218.jp2)
  49. Chapter5.Preparation of derivatives of TM for stereochemical studies / p215 (0221.jp2)
  50. SUMMARY / p217 (0223.jp2)
  51. REFERENCES / p218 (0224.jp2)
  52. ACKNOWLEDGMENTS / p223 (0229.jp2)
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Codes

  • NII Article ID (NAID)
    500000083182
  • NII Author ID (NRID)
    • 8000000083392
  • DOI(NDL)
  • NDLBibID
    • 000000247496
  • Source
    • NDL ONLINE
    • NDL Digital Collections

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