腹部多臓器同所性同種移植の実験的研究 : 24時間以上生存7例の検討 Orthotopic Allotransplantation of Multiple Abdominal Organs in Dogs フクブ タゾウキ ドウショセイ ドウシュ イショク ノ ジッケンテキ ケンキュウ : 24ジカン イジョウ セイゾン 7レイ ノ ケントウ

博士論文

Orthotopic allotransplantation of multiple abdominal organsi ncluding the liver，gallbladder，pancreas，spleen，kidneys，and gastrointestinal tract were attempted in dogs without any immuno-suppressant. Seven dogs tolerated the surgery and survived for 1-6 days. Four of them died of acute renal failure，a ssociated with sepsis，hypovolemia，and/or other troubles. Ischemic injury or rejection phenomenon was not seen histologically in the transplanted kidney. Despite am orphological satisfaction，watery diarrhea and hypoproteinemia required a continuous fluid replacement in all dogs. The transplanted liver and pancreas well functioned and maintained their morphological integrity throughout the observation time. An early death was occurred in two cases which revealed atelectasis secondary to perioperative respiratory infection. These findings suggested that the prevention of lethal infection and the support of sufficient nutrition in an early postoperative course are essential for the long survival in multiple abdominal organ transplantation.

医歯学総合研究科博士論文(医学) ; 学位取得日: 平成4年2月3日