Studies on zinc and neurotransmitters in the brain hippocampus under the restraint stress 拘束ストレスによる海馬中亜鉛および神経伝達物質の動態に関する研究
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Bibliographic Information
- Title
-
Studies on zinc and neurotransmitters in the brain hippocampus under the restraint stress
- Other Title
-
拘束ストレスによる海馬中亜鉛および神経伝達物質の動態に関する研究
- Author
-
伊藤, 俊弘
- Author(Another name)
-
イトウ, トシヒロ
- University
-
北海道大学
- Types of degree
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博士 (環境科学)
- Grant ID
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甲第3127号
- Degree year
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1992-12-25
Note and Description
博士論文
Table of Contents
- CONTENTS / (0003.jp2)
- I.INTRODUCTION / p1 (0007.jp2)
- 1.Zinc in central nervous system / p1 (0007.jp2)
- 1.1.Existence of zinc in the brain / p1 (0007.jp2)
- 1.2.Regional distribution of zinc in the brain / p2 (0008.jp2)
- 1.3.Subcellular distribution of zinc / p3 (0009.jp2)
- 1.4.Zinc in neurons / p3 (0009.jp2)
- 1.5.Co-localization of zinc with neurotransmitters and neuromodulators / p4 (0010.jp2)
- 1.6.Role of zinc in synaptic vesicles / p5 (0011.jp2)
- 2.Zinc and Stress / p8 (0014.jp2)
- 2.1.Stress and zinc metallothionein / p8 (0014.jp2)
- 2.2.Zinc and stress-induced gastric ulcer / p9 (0015.jp2)
- 2.3.Stress and hippocampal zinc / p9 (0015.jp2)
- 3.Purpose of the present study / p11 (0017.jp2)
- II.MATERIALS AND METHODS / p12 (0018.jp2)
- 1.In vivo Experiments / p12 (0018.jp2)
- 1.1.Changes in rat hippocampal zinc concentrations by restraint stress / p12 (0018.jp2)
- 1.2.Changes in synaptosomal zinc of rat hippocampus by restraint stress / p14 (0023.jp2)
- 1.3.Changes in rat plasma corticosterone levels induced by restraint stress / p17 (0027.jp2)
- 2.In situ Experiments / p19 (0029.jp2)
- 2.1.Characterization of endogenous zinc release in the hippocampus of the anesthetized rat by the brain microdialysis technique / p19 (0029.jp2)
- 2.2.Restraint stress induced changes in endogenous zinc release from the hippocampus of the free-moving rat analyzed by brain microdialysis / p21 (0033.jp2)
- III.RESULTS / p23 (0035.jp2)
- 1.In vivo Experiments / p23 (0035.jp2)
- 1.1.Zinc concentrations in rat hippocampal tissues / p23 (0035.jp2)
- 1.2.Zinc concentrations in synaptosomes of the rat hippocampus / p23 (0035.jp2)
- 1.3.Blood plasma corticosterone / p24 (0038.jp2)
- 2.In situ Experiments / p25 (0041.jp2)
- 2.1.Characterization of endogenous zinc release in the hippocampus of the anesthetized rat / p25 (0041.jp2)
- 2.2.Restraint stress-induced changes of endogenous zinc and amino acid concentrations in perfusate of hippocampus / p26 (0046.jp2)
- IV.DISCUSSION / p28 (0054.jp2)
- 1.Effect of the restraint stress on zinc in hippocampal tissue and its nerve endings / p28 (0054.jp2)
- 1.1.Zinc in hippocampal tissue / p28 (0054.jp2)
- 1.2.Zinc in both large and small synaptosomes of the hippocampus / p29 (0057.jp2)
- 1.3.Plasma corticosterone / p31 (0059.jp2)
- 2.Effect of restraint stress on neuronal and/or neuromodulatory activity of zinc and related putative amino acid transmitters / p32 (0060.jp2)
- 2.1.Characterization of endogenous zinc release / p32 (0060.jp2)
- 2.2.Endogenous zinc and amino acid release induced by restraint stress / p33 (0061.jp2)
- 3.Supplement discussion / p35 (0063.jp2)
- V.CONCLUSION / p36 (0064.jp2)
- ACKNOWLEDGMENTS / p38 (0066.jp2)
- REFERENCES / p40 (0068.jp2)