Opioid-regulated pharmacological interaction and intracellular signaling mechanism
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Bibliographic Information
- Title
-
Opioid-regulated pharmacological interaction and intracellular signaling mechanism
- Author
-
成田, 年
- Author(Another name)
-
ナリタ, ミノル
- University
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星薬科大学
- Types of degree
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博士 (薬学)
- Grant ID
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甲第53号
- Degree year
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1993-03-15
Note and Description
博士論文
Table of Contents
- TABLE OF CONTENTS / p1 (0003.jp2)
- GENERAL INTRODUCTION / p1 (0007.jp2)
- CHAPTER1 / p11 (0012.jp2)
- EFFECTS OF κ AGONISTS ON THE MORPHINE-INDUCED ANTINOCICEPTION, LOCOMOTION, STRAUB TAIL AND INCREASE IN DOPAMINE TURNOVER IN MICE / p11 (0012.jp2)
- EXPERIMENT1-1: Effects of κ agonist on the morphine-induced supraspinal antinociception / p15 (0014.jp2)
- EXPERIMENT1-2: Blockade of the morphine-induced hyperlocomotion by κ agonists in mice / p24 (0019.jp2)
- EXPERIMENT1-3: Antagonism of the morphine-induced Straub tail reaction by κ opioid receptor activation in mice / p35 (0024.jp2)
- EXPERIMENT1-4: Blockade of the morphine-induced increase in turnover of dopamine in the mesolimbic dopaminergic system by κ agonist in mice / p39 (0026.jp2)
- EXPERIMENT1-5: Lack of blockade of the morphine-induced increase in turnover of serotonin in the limbic forebrain by κ agonist in mice / p49 (0031.jp2)
- EXPERIMENT1-6: Interaction among the opioid receptor types in the double-enkephalins-induced antinociception and locomotor enhancing action in mice / p53 (0033.jp2)
- Discussion / p59 (0036.jp2)
- CHAPTER2 / p81 (0047.jp2)
- ROLE OF κ RECEPTORS IN THE DEVELOPMENT OF ANTINOCICEPTIVE TOLERANCE TO AND PHYSICAL DEPENDENCE ON MORPHINE / p81 (0047.jp2)
- EXPERIMENT2-1: Effects of κ agonist and dopamine blockers on the development of antinociceptive tolerance to morphine in mice / p84 (0049.jp2)
- EXPERIMENT2-2: Effects of κ antagonist on the development of tolerance to morphine antinociception in mice / p88 (0051.jp2)
- EXPERIMENT2-3: Effects of κ antagonist on the development of physical dependence on morphine in mice and rats / p94 (0054.jp2)
- Discussion / p102 (0058.jp2)
- CHAPTER3 / p108 (0061.jp2)
- ROLE OF CENTRAL ATP-SENSITIVE K⁺ CHANNELS IN THE MORPHINE-INDUCED PHARMACOLOGICAL ACTIONS / p108 (0061.jp2)
- EXPERIMENT3-1: Involvement of central ATP-sensitive K⁺ channel in the morphine-induced antinociception in mice / p110 (0062.jp2)
- EXPERIMENT3-2: Direct opeing of central ATP-sensitive K⁺ channels produces the antinociception in mice / p115 (0064.jp2)
- EXPERIMENT3-3: Lack of displacement of ³H-glibenclamide bindings by morphine in the mouse brain / p119 (0066.jp2)
- EXPERIMENT3-4: Involvement of central ATP-sensitive K⁺ channels in the spinal noradrenaline turnover-enhancing effect of intracere-broventricularly injected morphine in mice / p123 (0068.jp2)
- EXPERIMENT3-5: Direct opening of central ATP-sensitive K⁺ channels produces the spinal noradrenaline turnover-enhancing effect in mice / p128 (0071.jp2)
- EXPERIMENT3-6: Role of central ATP-sensitive K⁺ channels in the hyperthermic effect of morphine in mice / p131 (0072.jp2)
- EXPERIMENT3-7: Blockade of central ATP-sensitive K⁺ channels abolishes the potentiating effect of morphine on the bicucullineinduced convulsion in mice / p134 (0074.jp2)
- EXPERIMENT3-8: Lack of changes in central ATP-sensitive K⁺ channels in the morphine-tolerant mice / p139 (0076.jp2)
- Discussion / p147 (0080.jp2)
- SUMMARY / p161 (0087.jp2)
- ACKNOWLEDGEMENTS / p167 (0090.jp2)
- REFERENCES / p168 (0091.jp2)