Studies on the regulation of gene expression by extracellular stimulations 細胞外刺激による遺伝子発現調節の研究
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著者
書誌事項
- タイトル
-
Studies on the regulation of gene expression by extracellular stimulations
- タイトル別名
-
細胞外刺激による遺伝子発現調節の研究
- 著者名
-
菊地, 慶司
- 著者別名
-
キクチ, ケイジ
- 学位授与大学
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東京大学
- 取得学位
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博士 (工学)
- 学位授与番号
-
甲第9304号
- 学位授与年月日
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1992-03-16
注記・抄録
博士論文
目次
- Table of contents / (0003.jp2)
- 1 Introduction / p1 (0007.jp2)
- 1.1 Roles of the study of biological signal processing system in biotechnology / p1 (0007.jp2)
- 1.2 Requirements for the genes regulated by extracellular signals / p5 (0011.jp2)
- 1.3 Purpose and organization of this study / p6 (0012.jp2)
- 1.4 Extracellular stimulations and genetic response of the cells / p6 (0012.jp2)
- References / p8 (0014.jp2)
- 2 Identification of intracellular signaling molecules of lymphocytes / p10 (0016.jp2)
- 2.1 Background and concept of cell fusion experiment / p10 (0016.jp2)
- 2.2 Materials and methods / p13 (0019.jp2)
- 2.3 Results and discussion / p15 (0021.jp2)
- 2.4 Concluding remarks for this chapter / p18 (0024.jp2)
- References / p19 (0025.jp2)
- Figures and Tables / p20 (0026.jp2)
- 3 Analysis of constitutive transcription of a gene in lymphoid cells / p27 (0033.jp2)
- 3.1 Background / p27 (0033.jp2)
- 3.2 Materials and methods / p28 (0034.jp2)
- 3.3 Results / p32 (0038.jp2)
- 3.4 Discussion / p39 (0045.jp2)
- 3.5 Summary and conclusion of chapter3 / p45 (0051.jp2)
- References / p45 (0051.jp2)
- Figures and Tables / p48 (0054.jp2)
- 4 Effects of different types of extracellular stimuli on activation of gene transcription / p61 (0067.jp2)
- 4.1 Background / p61 (0067.jp2)
- 4.2 Materials and methods / p66 (0072.jp2)
- 4.3 Results / p69 (0075.jp2)
- 4.4 Discussion / p74 (0080.jp2)
- 4.5 Summary and conclusion of chapter4 / p78 (0084.jp2)
- References / p79 (0085.jp2)
- Figures and Tables / p82 (0088.jp2)
- 5 Kinetics of transcriptional activation mediated by transcriptional regulatory elements in response to extracellular stimuli / p94 (0100.jp2)
- 5.1 Background / p94 (0100.jp2)
- 5.2 Materials and methods / p97 (0103.jp2)
- 5.3 Results / p99 (0105.jp2)
- 5.4 Discussion / p106 (0112.jp2)
- 5.5 Summary and conclusion of chapter5 / p110 (0116.jp2)
- References / p111 (0117.jp2)
- Figures and Tables / p113 (0119.jp2)
- 6 Analysis of binding of transcriptional regulator protein to regulatory sequence element / p129 (0135.jp2)
- 6.1 Background / p129 (0135.jp2)
- 6.2 Materials and methods / p131 (0137.jp2)
- 6.3 Results / p133 (0139.jp2)
- 6.4 Discussion / p136 (0142.jp2)
- 6.5 Summary and conclusion of chapter6 / p137 (0143.jp2)
- References / p138 (0144.jp2)
- Figures / p139 (0145.jp2)
- 7 Conclusion and possible applications / p149 (0155.jp2)
- 7.1 Conclusion of this study / p149 (0155.jp2)
- 7.2 Applications / p151 (0157.jp2)
- Figures / p155 (0161.jp2)
- Appendix A:Transcriptional regulatory elements within the enhancer-promoter of the c-fos gene / p157 (0163.jp2)
- Appendix B:Function of the c-fos gene / p163 (0169.jp2)
- Acknowledgement / p167 (0173.jp2)