Fundamental studies and evaluations of irinotecan (CPT-11) : mechanisms of resistance to irinotecan and its cytotoxicity イリノテカンに関する基礎的研究及び評価 : イリノテカンに対する耐性機構とその細胞毒性
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Bibliographic Information
- Title
-
Fundamental studies and evaluations of irinotecan (CPT-11) : mechanisms of resistance to irinotecan and its cytotoxicity
- Other Title
-
イリノテカンに関する基礎的研究及び評価 : イリノテカンに対する耐性機構とその細胞毒性
- Author
-
武田, 左知
- Author(Another name)
-
タケダ, サチ
- University
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九州大学
- Types of degree
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博士 (薬学)
- Grant ID
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甲第3179号
- Degree year
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1993-06-18
Note and Description
博士論文
Table of Contents
- CONTENTS / (0003.jp2)
- Prologue / p1 (0005.jp2)
- Section I:Inhibitory Effect of CPT-11 on Liver metastasis of Human Pancreatic Tumor Cells in Nude Mice and Basic Evaluation of its Effectiveness to Human Pancreas Cancer / p2 (0006.jp2)
- Introduction / p2 (0006.jp2)
- Results / p4 (0007.jp2)
- Discussion / p10 (0010.jp2)
- Section II:Different Mechanisms of Resistance to CPT-11 Operating in Native-and Acquired-resistant Human Pancreatic Tumor Cell Lines / p12 (0011.jp2)
- Introduction / p12 (0011.jp2)
- Results / p13 (0011.jp2)
- Discussion / p23 (0016.jp2)
- Section III:CPT-11-Sensitive Human Pancreatic Tumor Cell Line,QGP-1N,Showing Resistance to SN-38,an Active Metabolite of CPT-11 / p26 (0018.jp2)
- Introduction / p26 (0018.jp2)
- Results / p27 (0018.jp2)
- Discussion / p34 (0022.jp2)
- Epilogue / p37 (0023.jp2)
- Acknowledgment / p38 (0024.jp2)
- Materials and methods / p39 (0024.jp2)
- References / p43 (0026.jp2)