Studies on the functions of platelet membrane glycoprotein Ⅰb and glycoprotein Ⅱb/Ⅲa using newly developed monoclonal antibodies 新たに作成したモノクローナル抗体を用いる血小板膜糖蛋白GPⅠbとGPⅡb/Ⅲaの機能に関する研究
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著者
書誌事項
- タイトル
-
Studies on the functions of platelet membrane glycoprotein Ⅰb and glycoprotein Ⅱb/Ⅲa using newly developed monoclonal antibodies
- タイトル別名
-
新たに作成したモノクローナル抗体を用いる血小板膜糖蛋白GPⅠbとGPⅡb/Ⅲaの機能に関する研究
- 著者名
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山本, 正雅
- 著者別名
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ヤマモト, ナオマサ
- 学位授与大学
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東京理科大学
- 取得学位
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博士 (薬学)
- 学位授与番号
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乙第348号
- 学位授与年月日
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1991-09-30
注記・抄録
博士論文
目次
- General Introduction / p1 (0006.jp2)
- Chapter I.PRODUCTION OF MONOCLONAL ANTIBODIES DIRECTED GLYCOPROTEIN Ib AND GLYCOPROTEIN IIIa / p3 (0008.jp2)
- I-1 Introduction / p3 (0008.jp2)
- I-2 Materials and Methods / p3 (0008.jp2)
- I-3 Results / p7 (0012.jp2)
- I-4 Discussion / p12 (0017.jp2)
- Chapter II.MONOCLONAL ANTIBODY, TM60 INHIBITS BOTH THROMBIN-AND RISTOCETIN-INDUCED PLATELET AGGREGATIONS / p14 (0019.jp2)
- II-1 Introduction / p14 (0019.jp2)
- II-2 Methods / p14 (0019.jp2)
- II-3 Results / p15 (0020.jp2)
- II-4 Discussion / p19 (0024.jp2)
- Chapter III.GLYCOPROTEIN Ib DISTRIBUTION ON THE SURFACE OF PLATELETS IN RESTING AND ACTIVATION STATES: AN ELECTRON MICROSCOPE STUDY / p21 (0026.jp2)
- III-1 Introduction / p21 (0026.jp2)
- III-2 Methods / p21 (0026.jp2)
- III-3 Results / p23 (0028.jp2)
- III-4 Discussion / p32 (0037.jp2)
- Chapter IV.CALCIUM IONS AND THE CONFORMATION OF GLYCOPROTEIN IIIa THAT IS ESSENTIAL FOR FIBRINOGEN BINDING TO PLATELETS: ANALYSIS BY NEW MONOCLONAL ANTI-GPIIIa ANTIBODY, TM83 / p35 (0040.jp2)
- IV-1 Introduction / p35 (0040.jp2)
- IV-2 Methods / p36 (0041.jp2)
- IV-3 Results / p39 (0044.jp2)
- IV-4 Discussion / p49 (0054.jp2)
- Chapter V.INVOLVEMENT OF PLATELET MEMBRANE GLYCOPROTEIN Ib AND GLYCOPROTEIN IIb/IIIa COMPLEX IN THROMBIN-DEPENDENT AND-INDEPENDENT PLATELET AGGREGATIONS INDUCED BY TUMOR CELLS / p53 (0058.jp2)
- V-1 Introduction / p53 (0058.jp2)
- V-2 Methods / p53 (0058.jp2)
- V-3 Results / p55 (0060.jp2)
- V-4 Discussion / p63 (0068.jp2)
- General discussion / p66 (0071.jp2)
- Conclusions / p69 (0074.jp2)
- Acknowledgement / p70 (0075.jp2)
- References / p71 (0076.jp2)