Antitumor activities and immunological studies by fucoidan (GIV-A) prepared from Sargassum thunbergii 褐藻ウミトラノオ由来フコイダンの抗腫瘍作用と免疫学的研究
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Bibliographic Information
- Title
-
Antitumor activities and immunological studies by fucoidan (GIV-A) prepared from Sargassum thunbergii
- Other Title
-
褐藻ウミトラノオ由来フコイダンの抗腫瘍作用と免疫学的研究
- Author
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伊藤, 浩子
- Author(Another name)
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イトウ, ヒロコ
- University
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三重大学
- Types of degree
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博士 (学術)
- Grant ID
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甲第533号
- Degree year
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1996-03-25
Note and Description
博士論文
Table of Contents
- CONTENTS / (0003.jp2)
- 1.Introduction / p1 (0005.jp2)
- 2.Materials / p4 (0008.jp2)
- 1)Algal specimens / p4 (0008.jp2)
- 2)Extraction, fractionation and purification of polysaccharides from seaweed / p4 (0008.jp2)
- 3)Chemical and physicochemical properties. / p6 (0010.jp2)
- 4)Chemicals / p7 (0011.jp2)
- 5)Animals / p7 (0011.jp2)
- 6)Tumors / p7 (0011.jp2)
- 3.Methods / p9 (0013.jp2)
- 1)Evaluation of antitumor activity on EAC / p9 (0013.jp2)
- 2)Evaluation of antitumor activity on 3LL / p9 (0013.jp2)
- 3)Cytocidal antitumor test / p10 (0014.jp2)
- 4)Assay of carbon clearance activity / p10 (0014.jp2)
- 5)Assay of crossed immunoelectrophoresis / p11 (0015.jp2)
- 6)Phagocytosis and ingestion of polystyrene latex beads / p12 (0016.jp2)
- 7)Preparation of effecter cells / p13 (0017.jp2)
- 8)The third component of complement(C3)cleavage product binding assay / p14 (0018.jp2)
- 9)Luminol-dependent chemiluminescence assay / p14 (0018.jp2)
- 10)Assay of residual CH50 / p15 (0019.jp2)
- 11)Picryl chloride-induced delayed type hypersensitivity / p15 (0019.jp2)
- 12)Assay of liver, spleen and thymus weights, number of spleen cells and quantitative hemolysis of sheep red blood cells(SRBC)[QHS] / p16 (0020.jp2)
- 13)Analysis of splenic lymphocyte subsets / p16 (0020.jp2)
- 14)Assay of hepatic drug-metabolizing enzyme / p18 (0022.jp2)
- 15)Assay of 5-FU / p19 (0023.jp2)
- 4.Results / p20 (0024.jp2)
- 1)Antitumor effect on Ehrlich ascites carcinoma / p20 (0024.jp2)
- 2)Inhibitions of growth of 3LL by GIV-A and 5-FU / p20 (0024.jp2)
- 3)Additive effects of GIV-A and/or 5-FU on lung metastases / p24 (0028.jp2)
- 4)Direct cytocidal action of GIV-A on tumor cells / p24 (0028.jp2)
- 5)Effect of the antitumor agents on the phagocytic activity in EAC-bearing mice / p26 (0030.jp2)
- 6)Effects on the liver, spleen and thymus weights, number of spleen cells and QHS / p26 (0030.jp2)
- 7)Effect on phagocytosis of peritoneal macrophages / p29 (0033.jp2)
- 8)C3 converting activity in human serum / p29 (0033.jp2)
- 9)Effect on CL and C3 cleavage production of macrophages / p33 (0037.jp2)
- 10)Effects of GIV-A on peritoneal macrophages or lung macrophages and induction of C3-positive macrophages / p33 (0037.jp2)
- 11)Inhibitions of i.v. injection of peritoneal macrophages activated with GIV-A on lung metastases / p39 (0043.jp2)
- 12)Effects of GIV-A and/or 5-FU on PC-DTH / p41 (0045.jp2)
- 13)Flow cytometric analyses of splenic lymphocyte subsets / p41 (0045.jp2)
- 14)Effects of GIV-A on drug-metabolism in the liver of 3LL-bearing mice / p44 (0048.jp2)
- 15)Chemical analysis of antitumor active polysaccharides / p46 (0050.jp2)
- 4.Discussion / p52 (0056.jp2)
- 5.Conclusion / p61 (0065.jp2)
- 6.Acknowledgments / p63 (0067.jp2)
- 7.Abstract in Japanese / p64 (0068.jp2)
- 8.References / p67 (0071.jp2)