Syntheses of fluorinated amino acid 含フッ素アミノ酸の合成
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著者
書誌事項
- タイトル
-
Syntheses of fluorinated amino acid
- タイトル別名
-
含フッ素アミノ酸の合成
- 著者名
-
閻, 鳳洋
- 著者別名
-
エン, ホウヨウ
- 学位授与大学
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岡山大学
- 取得学位
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博士 (工学)
- 学位授与番号
-
甲第1471号
- 学位授与年月日
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1996-03-25
注記・抄録
博士論文
目次
- Contents / (0003.jp2)
- Chapter1 General Introduction / p1 (0004.jp2)
- 1-1.General lntroduction / p2 (0005.jp2)
- 1-2.Biological Activity of Fluorine-containing Amino Acid / p5 (0007.jp2)
- 1-3.Building Block Method for Racemic Florinated Amino Acids / p7 (0008.jp2)
- 1-4.Asymmetric Syntheses of Fluorine-Containing Amino Acids / p11 (0010.jp2)
- 1-5.General Summary / p17 (0013.jp2)
- 1-6.References / p19 (0014.jp2)
- Chapter2 Generation and Stabilization of Trifluoroacetimidoyl Carbanion:A Convenient Method for 2-Trifluoromethyl-2-imino Esters / p25 (0017.jp2)
- 2-1.Introduction / p26 (0018.jp2)
- 2-2.Generation of Trifluoroacetimidoyl Lithium / p28 (0019.jp2)
- 2-3.Stabilization of Trifluoroacetimidoyl Lithium / p29 (0020.jp2)
- 2-4.The Reaction of Imidoyl Carbanion / p35 (0023.jp2)
- 2-5.Experimental Section / p37 (0024.jp2)
- 2-6.References / p43 (0027.jp2)
- Chapter3 Asymmetric Reduction of 2-(N-Arylimino)-3,3,3-trifluoro-propanoic Acid Esters Leading to Enantiomerically Enriched3,3,3-Trifluoroalanine / p46 (0028.jp2)
- 3-1.Introduction / p47 (0029.jp2)
- 3-2.Preparation of Imino Esters / p49 (0030.jp2)
- 3-3.Asymmetric Reduction of Imino Esters / p50 (0031.jp2)
- 3-4.Reaction Mechanism / p54 (0033.jp2)
- 3-5.Synthesis of Enantiomerically Enriched 3,3,3-Trifluoroalanine / p56 (0034.jp2)
- 3-6.Determination of Absolute Configuration of Amino Esters / p56 (0034.jp2)
- 3-7.Experimental Section / p59 (0035.jp2)
- 3-8.References / p68 (0040.jp2)
- Chapter4 Asymmetric Alkylation of 2-(N-Arylimino)-3,3,3-trifluoro-propanoic Acid Esters and the Corresponding Cyclic Imines / p72 (0042.jp2)
- 4-1.Introduction / p73 (0043.jp2)
- 4-2.Synthesis of Cyclic Imines / p74 (0044.jp2)
- 4-3.Asymmetric Alkylation / p77 (0045.jp2)
- 4-4.Experimental Section / p79 (0046.jp2)
- 4-5.References / p82 (0048.jp2)
- Chapter5 Preparation and Utilization of 2-(N-Aryl-N-ethylamino)-3,3-difluoropropenoates / p84 (0049.jp2)
- 5.1.Introduction / p85 (0050.jp2)
- 5-2.Preparation of Difluoroolefins with Organometallic Reagents / p86 (0051.jp2)
- 5-3.Reaction Mechanism / p91 (0053.jp2)
- 5-4.Transformation of Difluoroolefin into Difluorinated Amino Acid Derivatives / p95 (0055.jp2)
- 5-5.Experimental Section / p97 (0056.jp2)
- 5-6.References / p102 (0059.jp2)
- Acknowledgments / p105 (0060.jp2)