Synthesis of sulfur-containing triazole antifungal agents 硫黄原子を有するトリアゾール系抗真菌剤の合成研究
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Bibliographic Information
- Title
-
Synthesis of sulfur-containing triazole antifungal agents
- Other Title
-
硫黄原子を有するトリアゾール系抗真菌剤の合成研究
- Author
-
宮内, 浩
- Author(Another name)
-
ミヤウチ, ヒロシ
- University
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北海道大学
- Types of degree
-
博士 (理学)
- Grant ID
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乙第4897号
- Degree year
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1996-03-25
Note and Description
博士論文
Table of Contents
- CONTENTS / (0004.jp2)
- GENERAL INTRODUCTION / p1 (0006.jp2)
- SECTION1 SYNTHESIS OF TRIAZOLE ANTIFUNGAL AGENT SM-8668 AND ITS BIOLOGICALLY ACTIVE ENANTIOMER SM-9164 / p7 (0012.jp2)
- Chapter1-1 Diastereoselective Synthesis of dl-threo-2-(2,4-Difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1 -yl)-2-butanol(SM-8668) / p8 (0013.jp2)
- Chapter1-2 Optical Resolution of SM-8668: Preparation and Antifungal Activity of Enantiomers of SM-8668 / p15 (0020.jp2)
- Chapter1-3 Stereospecific Acetolysis of threo- and erythro-2-Aryl-2-[1-(methylthio)ethyl]oxiranes / p20 (0025.jp2)
- Chapter1-4 Optical Resolution of dl-threo-2-(2,4-Difluorophenyl)-2-[1-(methylthio)ethyl]oxirane. Its Application to Synthesis of SM-9164, a Biologically Active Enantiomer of SM-8668 / p28 (0033.jp2)
- Chapter1-5 Studies on Enantioselective Synthesis of SM-9164 / p36 (0041.jp2)
- SECTION2 SYNTHESIS AND THE STRUCTURE-ACTIVITY RELATIONSHIPS OF SULFUR-CONTAINING TRIAZOLE ANTIFUNGALS / p45 (0050.jp2)
- Chapter2-1 Synthesis and Antifungal Activity of Alkylthio and Alkylsulfonyl Derivatives of SM-8668 / p46 (0051.jp2)
- Chapter 2-2 Synthesis and Antifungal Activity of 3-Methyl and 3,3-Dimethyl Analogs of 2(2,4-Difluorophenyl)-3-(ω-substituted alkyl)sulfonyl-1-(1H-1,2,4-triazol-l-yl)-2-propanols / p54 (0059.jp2)
- SUMMARY AND GENERAL CONCLUSION / p65 (0070.jp2)
- EXPERIMENTAL / p69 (0074.jp2)
- REFERENCES / p160 (0165.jp2)
- ACKNOWLEDGMENT / p169 (0174.jp2)