Synthesis and antitumor activity of duocarmycin derivatives デュオカルマイシン誘導体の合成と抗腫瘍活性
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著者
書誌事項
- タイトル
-
Synthesis and antitumor activity of duocarmycin derivatives
- タイトル別名
-
デュオカルマイシン誘導体の合成と抗腫瘍活性
- 著者名
-
長村, 聡仁
- 著者別名
-
ナガムラ, サトル
- 学位授与大学
-
九州大学
- 取得学位
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博士 (薬学)
- 学位授与番号
-
乙第6418号
- 学位授与年月日
-
1997-03-27
注記・抄録
博士論文
目次
- CONTENTS / p2 (0003.jp2)
- ABBREVIATIONS / p4 (0004.jp2)
- GENERAL INTRODUCTION / p5 (0004.jp2)
- CHAPTER I / p11 (0007.jp2)
- Modification of the Phenolic Hydroxyl Group / p11 (0007.jp2)
- I-1 Introduction / p11 (0007.jp2)
- I-2 Synthesis of Derivatives Modified at the Phenolic Hydroxy Group / p14 (0009.jp2)
- I-3 Stability of Duocarmycins and Duocarmycin B2 Derivatives under Various Conditions / p14 (0009.jp2)
- I-4 Biological Results and Discussion / p19 (0011.jp2)
- CHAPTER II / p23 (0013.jp2)
- Synthesis of A-Ring Pyrrole Derivatives / p23 (0013.jp2)
- II-1 Introduction / p23 (0013.jp2)
- II-2 Modification of the A-Ring Part of Duocarmycin B2 / p24 (0014.jp2)
- II-3 Carbamoylation of the A-Ring Pyrrole Analogs of Duocarmycin B2 / p28 (0016.jp2)
- II-4 Synthesis of A-Ring Pyrrole Analogs of Duocarmycin Bl / p29 (0016.jp2)
- II-5 Stability of the A-Ring Pyrrole Analogs in Aqueous Solution and in Calf Serum / p34 (0019.jp2)
- II-6 Biological Results and Discussion / p37 (0020.jp2)
- CHAPTER III / p42 (0023.jp2)
- Studies on the Mode of Action for KW-2189 Mediated Antitumor Activity / p42 (0023.jp2)
- III-1 Introduction / p42 (0023.jp2)
- III-2 Synthesis of the A-Ring Pyrrole Analogs Modified at the C-8 Position / p44 (0024.jp2)
- III-3 Biological Results and Discussion / p48 (0026.jp2)
- CHAPTER IV / p51 (0027.jp2)
- Studies on the Active Metabolite(DU-86)of KW-2189 / p51 (0027.jp2)
- IV-1 Introduction / p51 (0027.jp2)
- IV-2 Synthesis of DU-86 Analogs / p51 (0027.jp2)
- IV-3 Biological Results and Discussion / p54 (0029.jp2)
- SUMMARY OF THE ORIGINAL WORK / p56 (0030.jp2)
- EXPERIMENTAL SECTION / p58 (0031.jp2)
- ACKNOWLEDGMENT / p101 (0052.jp2)
- REFERENCES AND NOTES / p102 (0053.jp2)
- LIST OF PUBLICATIONS / p108 (0056.jp2)