Structural studies on the interactions of aureoic acid family antitumor antibiotics with DNA オーレオリック酸類抗癌剤とDNAとの相互作用の構造研究

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Title: Structural studies on the interactions of aureoic acid family antitumor antibiotics with DNA

博士論文

Contents / (0003.jp2)
Chapter 1.General Introduction / p1 (0004.jp2)
1-1.The aim of this thesis / p2 (0005.jp2)
1-2.DNA-drug interactions / p2 (0005.jp2)
1-2.Aureolic acid compounds / p5 (0007.jp2)
1-3.Conformation of DNA / p7 (0008.jp2)
1-4.NMR / p11 (0010.jp2)
1-5.DNA unwinding / p18 (0014.jp2)
Chapter 2.Novel Antitumor Drug, UCH9 / p21 (0015.jp2)
2-1.Introduction / p22 (0016.jp2)
2-2.Materials and Methods / p23 (0016.jp2)
2-3.Results / p25 (0017.jp2)
2-4.Discussion / p38 (0024.jp2)
Chapter 3.DNA Unwindg Assay of Aureolic Acid Compounds / p40 (0025.jp2)
3-1.Introduction / p41 (0025.jp2)
3-2.Materials and Methods / p43 (0026.jp2)
3-3.Results and Discussion / p44 (0027.jp2)
Chapter 4.Photo-CIDNP Experiment / p49 (0029.jp2)
4-1.Introduction / p50 (0030.jp2)
4-2.Materials and Methods / p51 (0030.jp2)
4-3.Results / p51 (0030.jp2)
4-4.Discussion / p58 (0034.jp2)
Chapter 5.Structure Analysis of Free d(GGGGCCCC)₂ and the ChromomycinA₃-d(GGGGCCCC)₂ Complex by NMR / p63 (0036.jp2)
5-1.Introduction / p64 (0037.jp2)
5-2.Materials and Methods / p65 (0037.jp2)
5-3.Results / p67 (0038.jp2)
5-4.Discussion / p80 (0045.jp2)
Chapter 6.Structure Determination of UCH9-d(TTGGCCAA)₂ Complex by NMR / p93 (0052.jp2)
6-1.Introduction / p94 (0052.jp2)
6-2.Materials and Methods / p97 (0054.jp2)
6-3.Results / p99 (0055.jp2)
6-4.Discussion / p115 (0063.jp2)
General Discussion and Conclusion / p125 (0069.jp2)
List of publications / p130 (0072.jp2)
Acknowledgements / p132 (0073.jp2)

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