Conformational properties of amino acid residues in the active site of bovine pancreatic ribonuclease A ウシ膵臓リボヌクレーゼAの活性中心アミノ酸残基の配向特性

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著者

    • 谷水, 直樹 タニミズ, ナオキ

書誌事項

タイトル

Conformational properties of amino acid residues in the active site of bovine pancreatic ribonuclease A

タイトル別名

ウシ膵臓リボヌクレーゼAの活性中心アミノ酸残基の配向特性

著者名

谷水, 直樹

著者別名

タニミズ, ナオキ

学位授与大学

京都大学

取得学位

博士(農学)

学位授与番号

甲第7960号

学位授与年月日

1999-05-24

注記・抄録

博士論文

目次

  1. 論文目録 / (0001.jp2)
  2. Contents / (0004.jp2)
  3. Abbreviations / (0005.jp2)
  4. Introduction / p1 (0006.jp2)
  5. Chapter1.History and recent studies of RNase A / p2 (0007.jp2)
  6. I.Introduction / p2 (0007.jp2)
  7. II.Production of RNase A in vitro / p3 (0007.jp2)
  8. III.Structure of substrate binding site / p5 (0008.jp2)
  9. IV.Folding and unfolding / p11 (0011.jp2)
  10. V.Biological function / p20 (0016.jp2)
  11. Chapter2.Role of catalytic residues in the activity and structure of RNase A / p28 (0020.jp2)
  12. I.Introduction / p28 (0020.jp2)
  13. II.Preparation and structural properties of catalytic histidine mutant enzymes / p32 (0022.jp2)
  14. III.Kinetic analysis / p33 (0022.jp2)
  15. IV.Structural stability / p36 (0024.jp2)
  16. V.Discussion / p38 (0025.jp2)
  17. VI.Summary / p40 (0026.jp2)
  18. Chapter3.Role of active-site surrounding amino acid residues in construction of the active site of RNase A / p41 (0026.jp2)
  19. Section1.Role of Phe120 in the activity and structure of RNase A / p41 (0026.jp2)
  20. I.Introduction / p41 (0026.jp2)
  21. II.Preparation and structural properties of Phe120 mutant enzymes / p43 (0027.jp2)
  22. III.Kinetic analysis / p46 (0029.jp2)
  23. IV.Discussion / p48 (0030.jp2)
  24. V.Summary / p52 (0032.jp2)
  25. Section2.Role of Asn44 in the activity of RNase A / p56 (0035.jp2)
  26. I.Introduction / p56 (0035.jp2)
  27. II.Preparation and structural properties of N44A / p57 (0035.jp2)
  28. III.Kinetic analysis and chemical modification / p57 (0035.jp2)
  29. IV.Discussion / p59 (0036.jp2)
  30. Chapter4.Role of Phe120 in the thermal stability and folding / p61 (0037.jp2)
  31. I.Introduction / p61 (0037.jp2)
  32. II.Thermal stability of Phe120 mutant enzymes / p64 (0039.jp2)
  33. III.Refolding / p65 (0039.jp2)
  34. IV.Discussion / p73 (0043.jp2)
  35. V.Summary / p74 (0044.jp2)
  36. Chapter5.Role of Gly68 in the activity and structure of RNase A / p76 (0045.jp2)
  37. I.Introduction / p76 (0045.jp2)
  38. II.Preparation and structural properties of G68V mutant enzyme / p77 (0046.jp2)
  39. III.Kinetic analysis / p78 (0046.jp2)
  40. IV.Refolding / p78 (0046.jp2)
  41. V.Discussion / p80 (0047.jp2)
  42. VI.Summary / p81 (0048.jp2)
  43. Conclusion / p82 (0048.jp2)
  44. Appendix / p85 (0050.jp2)
  45. Acknowledgment / p90 (0053.jp2)
  46. References / p91 (0053.jp2)
  47. Publications / p105 (0060.jp2)
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各種コード

  • NII論文ID(NAID)
    500000173401
  • NII著者ID(NRID)
    • 8000000173677
  • DOI(NDL)
  • NDL書誌ID
    • 000000337715
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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