Inhibitory effects of Sudanese medicinal plants and their constituents on the proteases of hepatitis C and human immunodeficiency viruses

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著者

    • Ghazi Mohamed Eisa Hussein ガージ モハメッド イーサ ホセイン

書誌事項

タイトル

Inhibitory effects of Sudanese medicinal plants and their constituents on the proteases of hepatitis C and human immunodeficiency viruses

著者名

Ghazi Mohamed Eisa Hussein

著者別名

ガージ モハメッド イーサ ホセイン

学位授与大学

富山医科薬科大学

取得学位

博士(薬学)

学位授与番号

甲第346号

学位授与年月日

1999-03-10

注記・抄録

博士論文

目次

  1. CONTENTS / p1 (0004.jp2)
  2. General Part / p1 (0007.jp2)
  3. Introduction / p1 (0007.jp2)
  4. I.General / p2 (0008.jp2)
  5. II.Development of anti-HCV agents / p2 (0008.jp2)
  6. III.Development of anti-HIV agents / p6 (0012.jp2)
  7. IV.Anti- HCV and anti- HIV agents from medicinal plants / p6 (0012.jp2)
  8. Chapter1.Screening of medicinal plants for their inhibitory effects on hepatitis C virus protease(HCV PR) / p7 (0013.jp2)
  9. 1.1.Inhibitory effects on HCV PR / p8 (0014.jp2)
  10. 1.2.Extracts with high inhibitory effects on HCV PR / p12 (0018.jp2)
  11. 1.3.Conclusion / p12 (0018.jp2)
  12. Chapter2.HCV PR inhibitory substances from Embelia schimperi / p13 (0019.jp2)
  13. 2.1.Embelia schimperi Vatke(Myrsinacea) / p14 (0020.jp2)
  14. 2.2. Extraction and isolation of HCV PR inhibitory substances from E.schimperi / p14 (0020.jp2)
  15. 2.3.Structure determination / p14 (0020.jp2)
  16. 2.4.Inhibitory activity of compounds isolated from E.schimperi on HCV PR / p21 (0027.jp2)
  17. 2.5.Inhibitory activity of derivatives of compound 2 on HCV PR / p23 (0029.jp2)
  18. 2.6.Effects of HCV PR inhibitory substances on other serine proteases,chymotrypsin, α-thrombin and trypsin / p23 (0029.jp2)
  19. 2.7.Conclusion / p24 (0030.jp2)
  20. Chapter3.Screening of medicinal plants for their inhibitory effects on human immunodeficiency virus type-1 protease (HIV-1 PR) / p25 (0031.jp2)
  21. 3.1.Inhibitory effects on HIV-1 PR / p26 (0032.jp2)
  22. 3.2.Tannin content and the inhibitory effects on HIV-1 PR / p26 (0032.jp2)
  23. 3.3.Effects of plant extracts on the replication of HIV-1 in MT-4 cells Inhibition of HIV-1 induced cytopathic effect(CPE)on MT-4 cells / p29 (0035.jp2)
  24. 3.4.Conclusion / p30 (0036.jp2)
  25. Chapter4.HIV-1 PR inhibitory substances from Maytenus senegalensis / p31 (0037.jp2)
  26. 4.1.Maytenus senegalensis(Lam.)Exell(Celastraceae) / p32 (0038.jp2)
  27. 4.2.Extraction and isolation of HIV-1 PR inhibitory substances from M. senegalensis / p32 (0038.jp2)
  28. 4.3.Structure determination / p32 (0038.jp2)
  29. 4.4.Inhibitory effects of compounds isolated from M.senegalensis on HIV-1 PR / p41 (0047.jp2)
  30. 4.5.Conclusion / p43 (0049.jp2)
  31. Discussion / p45 (0051.jp2)
  32. Experimental Part / p48 (0054.jp2)
  33. General / p49 (0055.jp2)
  34. 1.Assay methods used for screening HCV PR inhibitory activity / p49 (0055.jp2)
  35. 2.Extraction,separation and properties of compounds isolated from Embelia schimperi / p51 (0057.jp2)
  36. 3.Assay methods for other serine proteases / p57 (0063.jp2)
  37. 4.Assay method used for screening HIV-1 PR inhibitory activity / p59 (0065.jp2)
  38. 5.Determination of tannin content in plant extracts / p60 (0066.jp2)
  39. 6.Assay method for testing the effects on the replication of HIV-1 in MT-4 cell / p60 (0066.jp2)
  40. 7.Extraction,separation and properties of compounds isolated from Maytenus senegalensis / p61 (0067.jp2)
  41. Acknowledgements / p67 (0073.jp2)
  42. References / p69 (0075.jp2)
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各種コード

  • NII論文ID(NAID)
    500000174552
  • NII著者ID(NRID)
    • 8000000174829
  • DOI(NDL)
  • NDL書誌ID
    • 000000338866
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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