Study on evaluation of drug absorption and stability using a human intestinal adenocarcinoma cell line Caco-2 ヒト大腸癌由来細胞株Caco-2を用いた薬物の消化管吸収性及び安定性の評価に関する研究

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著者

    • 權, 英淑 ケン, エイシュク

書誌事項

タイトル

Study on evaluation of drug absorption and stability using a human intestinal adenocarcinoma cell line Caco-2

タイトル別名

ヒト大腸癌由来細胞株Caco-2を用いた薬物の消化管吸収性及び安定性の評価に関する研究

著者名

權, 英淑

著者別名

ケン, エイシュク

学位授与大学

京都薬科大学

取得学位

博士(薬学)

学位授与番号

甲第36号

学位授与年月日

1999-03-20

注記・抄録

博士論文

目次

  1. CONTENTS / p1 (0003.jp2)
  2. PREFACE / p1 (0005.jp2)
  3. ABBREVIATIONS / p2 (0006.jp2)
  4. Chapter I Determination of Enhancing Effects and Cytotoxicity of Absorption Enhancers in Caco-2 Cell Monolayers / p3 (0007.jp2)
  5. I-1 Enhancing and Cytotoxic Effects of Absorption Enhancers / p3 (0007.jp2)
  6. I-2 Relationship between the Enhancement Effects and Cytotoxicity of Absorption Enhancers / p7 (0011.jp2)
  7. I-3 Recovery of Transepithelial Electrical Resistance in Caco-2 Cell Monolayers after Exposure to Absorption Enhancers / p7 (0011.jp2)
  8. I-4 In Vitro-in Vivo Correlation / p9 (0013.jp2)
  9. I-5 Discussion / p9 (0013.jp2)
  10. Chapter II Transport Characteristics of Leucine-Enkephalin across Intestinal Membrane Using Caco-2 Model:Quantitative Analysis for Contribution of Enzymatic and Transport Barrier / p15 (0019.jp2)
  11. II-1 Measurement of Aminopeptidase Activities / p16 (0020.jp2)
  12. II-2 Transport Kinetics of Leucine-Enkephalin across Caco-2 Cell Monolayers in the Presence of Protease Inhibitors / p18 (0022.jp2)
  13. II-3 Cytotoxicity of Protease Inhibitors in Caco-2 Cells / p20 (0024.jp2)
  14. II-4 Discussion / p22 (0026.jp2)
  15. Chapter III Transport Characteristics of Tetragastrin across Intestinal Membrane Using Caco-2 Model:Comparison between Acylation and Application of Protease Inhibitors / p25 (0029.jp2)
  16. III-1 Acylation of Tetragastrin for Improving Its Transport and Stability / p26 (0030.jp2)
  17. III-2 Effects of Protease Inhibitors on the Transport of Tetragastrin across Caco-2 Cell Monolayers / p28 (0032.jp2)
  18. III-3 Transport Kinetics of Tetragastrin and Its Acyl Derivatives across Caco-2 Cell Monolayers in the Presence of Protease Inhibitors / p30 (0034.jp2)
  19. III-4 Discussion / p31 (0035.jp2)
  20. Chapter IV Electrophysiological Studies for the Evaluation of Absorption Enhancers in Caco-2 Cells Using a Microelectrode Technique / p37 (0041.jp2)
  21. IV-1 Electrophysiological Studies in Caco-2 Cells / p37 (0041.jp2)
  22. IV-2 Effects of Absorption Enhancers on the Transport Pathways in Caco-2 Cell Monolayers / p41 (0045.jp2)
  23. IV-3 Relationship between the Change of Apical Membrane Potential and the Transcellular Transport of Furosemide in the Presence or Absence of Absorption Enhancers / p43 (0047.jp2)
  24. IV-4 Discussion / p44 (0048.jp2)
  25. CONCLUSION / p48 (0052.jp2)
  26. ACKNOWLEDGMENTS / p52 (0056.jp2)
  27. EXPERIMENTAL SECTION / p53 (0057.jp2)
  28. REFERENCES / p63 (0067.jp2)
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各種コード

  • NII論文ID(NAID)
    500000174654
  • NII著者ID(NRID)
    • 8000000174931
  • DOI(NDL)
  • NDL書誌ID
    • 000000338968
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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