Study on evaluation of drug absorption and stability using a human intestinal adenocarcinoma cell line Caco-2 ヒト大腸癌由来細胞株Caco-2を用いた薬物の消化管吸収性及び安定性の評価に関する研究
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著者
書誌事項
- タイトル
-
Study on evaluation of drug absorption and stability using a human intestinal adenocarcinoma cell line Caco-2
- タイトル別名
-
ヒト大腸癌由来細胞株Caco-2を用いた薬物の消化管吸収性及び安定性の評価に関する研究
- 著者名
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權, 英淑
- 著者別名
-
ケン, エイシュク
- 学位授与大学
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京都薬科大学
- 取得学位
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博士(薬学)
- 学位授与番号
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甲第36号
- 学位授与年月日
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1999-03-20
注記・抄録
博士論文
目次
- CONTENTS / p1 (0003.jp2)
- PREFACE / p1 (0005.jp2)
- ABBREVIATIONS / p2 (0006.jp2)
- Chapter I Determination of Enhancing Effects and Cytotoxicity of Absorption Enhancers in Caco-2 Cell Monolayers / p3 (0007.jp2)
- I-1 Enhancing and Cytotoxic Effects of Absorption Enhancers / p3 (0007.jp2)
- I-2 Relationship between the Enhancement Effects and Cytotoxicity of Absorption Enhancers / p7 (0011.jp2)
- I-3 Recovery of Transepithelial Electrical Resistance in Caco-2 Cell Monolayers after Exposure to Absorption Enhancers / p7 (0011.jp2)
- I-4 In Vitro-in Vivo Correlation / p9 (0013.jp2)
- I-5 Discussion / p9 (0013.jp2)
- Chapter II Transport Characteristics of Leucine-Enkephalin across Intestinal Membrane Using Caco-2 Model:Quantitative Analysis for Contribution of Enzymatic and Transport Barrier / p15 (0019.jp2)
- II-1 Measurement of Aminopeptidase Activities / p16 (0020.jp2)
- II-2 Transport Kinetics of Leucine-Enkephalin across Caco-2 Cell Monolayers in the Presence of Protease Inhibitors / p18 (0022.jp2)
- II-3 Cytotoxicity of Protease Inhibitors in Caco-2 Cells / p20 (0024.jp2)
- II-4 Discussion / p22 (0026.jp2)
- Chapter III Transport Characteristics of Tetragastrin across Intestinal Membrane Using Caco-2 Model:Comparison between Acylation and Application of Protease Inhibitors / p25 (0029.jp2)
- III-1 Acylation of Tetragastrin for Improving Its Transport and Stability / p26 (0030.jp2)
- III-2 Effects of Protease Inhibitors on the Transport of Tetragastrin across Caco-2 Cell Monolayers / p28 (0032.jp2)
- III-3 Transport Kinetics of Tetragastrin and Its Acyl Derivatives across Caco-2 Cell Monolayers in the Presence of Protease Inhibitors / p30 (0034.jp2)
- III-4 Discussion / p31 (0035.jp2)
- Chapter IV Electrophysiological Studies for the Evaluation of Absorption Enhancers in Caco-2 Cells Using a Microelectrode Technique / p37 (0041.jp2)
- IV-1 Electrophysiological Studies in Caco-2 Cells / p37 (0041.jp2)
- IV-2 Effects of Absorption Enhancers on the Transport Pathways in Caco-2 Cell Monolayers / p41 (0045.jp2)
- IV-3 Relationship between the Change of Apical Membrane Potential and the Transcellular Transport of Furosemide in the Presence or Absence of Absorption Enhancers / p43 (0047.jp2)
- IV-4 Discussion / p44 (0048.jp2)
- CONCLUSION / p48 (0052.jp2)
- ACKNOWLEDGMENTS / p52 (0056.jp2)
- EXPERIMENTAL SECTION / p53 (0057.jp2)
- REFERENCES / p63 (0067.jp2)