Maxizyme, a novel RNA motif with high potential as gene-inactivating agent 新規RNAモチーフであるマキシザイムの創製と遺伝子治療への応用
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著者
書誌事項
- タイトル
-
Maxizyme, a novel RNA motif with high potential as gene-inactivating agent
- タイトル別名
-
新規RNAモチーフであるマキシザイムの創製と遺伝子治療への応用
- 著者名
-
桑原, 知子
- 著者別名
-
クワバラ, トモコ
- 学位授与大学
-
筑波大学
- 取得学位
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博士 (農学)
- 学位授与番号
-
甲第2050号
- 学位授与年月日
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1999-03-25
注記・抄録
博士論文
1998
目次
- Contents / (0003.jp2)
- Chapter I General introduction / p1 (0007.jp2)
- Chapter II Characterization of several kinds of dimeric minizyme:simultaneous cleavage at two sites in HIV-1 tat mRNA by dimeric minizymes in vitro / p12 (0018.jp2)
- Introduction / p13 (0019.jp2)
- Materials and Methods / p19 (0025.jp2)
- Results / p23 (0029.jp2)
- Discussion / p32 (0038.jp2)
- Chapter III Formation in vitro and in cells of a catalytically active dimer by tRNA Val-driven short ribozymes / p33 (0039.jp2)
- Introduction / p34 (0040.jp2)
- Materials and Methods / p37 (0043.jp2)
- Results / p43 (0049.jp2)
- Discussion / p56 (0062.jp2)
- Chapter IV Novel tRNA Val-heterodimeric minizymes with high potential as gene-inactivating agents:Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells / p57 (0063.jp2)
- Introduction / p58 (0064.jp2)
- Materials and Methods / p62 (0068.jp2)
- Results / p65 (0071.jp2)
- Discussion / p77 (0083.jp2)
- Chapter V A novel allosterically trans-activated ribozyme(maxizyme)with exceptional specificity in vitro and in vivo / p81 (0087.jp2)
- Introduction / p82 (0088.jp2)
- Materialsand Methods / p91 (0097.jp2)
- Results / p95 (0101.jp2)
- Discussion / p117 (0123.jp2)
- Chapter VI General discussion / p118 (0124.jp2)
- Acknowledgements / p124 (0130.jp2)
- References / p125 (0131.jp2)