Correlation between cytotoxicity and structural aspect of CDDP derivatives, and roles of CDDP cross-linking in HMG1 binding DNA structure CDDP誘導体の構造活性相関ならびにHMG1結合DNA鎖構造におけるCDDP架橋の役割
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著者
書誌事項
- タイトル
-
Correlation between cytotoxicity and structural aspect of CDDP derivatives, and roles of CDDP cross-linking in HMG1 binding DNA structure
- タイトル別名
-
CDDP誘導体の構造活性相関ならびにHMG1結合DNA鎖構造におけるCDDP架橋の役割
- 著者名
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堂田, 征史
- 著者別名
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ドウダ, ユキフミ
- 学位授与大学
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筑波大学
- 取得学位
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博士 (理学)
- 学位授与番号
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甲第2075号
- 学位授与年月日
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1999-03-25
注記・抄録
博士論文
The antitumor activity of the inorganic drug, cisplatin (cisdiamminedichloroplatinum(II); CDDP), was recognized almost three decades ago. Now the long-term survival for testicular cancer patients treated with cisplatin exceeds 90% in clinical use. If the detailed action mechanism of this anticancer drug could be ...
1998
目次
- Contents / (0003.jp2)
- Chapter 1. Introduction / p1 (0008.jp2)
- Chapter 2. Experimental / p7 (0014.jp2)
- §1. General / p7 (0014.jp2)
- §2. Methods of Synthesis / p14 (0021.jp2)
- §3. Methods of Measurements / p49 (0056.jp2)
- Chapter3. Results and Discussion / p68 (0075.jp2)
- §1. The cis-Diammineplatinum(II) Complexes with Pyrimidine, Imide and Proteins / p68 (0075.jp2)
- §2. MALDI-TOF MASS Spectra of Platinated Oligodeoxynucleotides and Protein / p134 (0141.jp2)
- §3. Model Scheme of Solid Phase Synthesis of CDDP-Modified Oligodeoxynucleotides / p140 (0147.jp2)
- §4. Fluorescence Analysis of CDDP-Modified Oligodeoxynucleotides / p168 (0175.jp2)
- §5. Disordering of HMG1 Domains Binding ¹⁵N-Labeled Platinum-DNA / p228 (0235.jp2)
- Chapter4. Conclusions / p238 (0245.jp2)
- References / p244 (0251.jp2)
- Acknowledgments / p250 (0257.jp2)
