Two intracellular singaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth 酸化低密度リポ蛋白質によるマクロファージ増殖には,2つの経路を介するプロテインキナーゼCの活性化が関与する

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著者

    • 松村, 剛 マツムラ, タケシ

書誌事項

タイトル

Two intracellular singaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth

タイトル別名

酸化低密度リポ蛋白質によるマクロファージ増殖には,2つの経路を介するプロテインキナーゼCの活性化が関与する

著者名

松村, 剛

著者別名

マツムラ, タケシ

学位授与大学

熊本大学

取得学位

博士 (医学)

学位授与番号

甲第1195号

学位授与年月日

1999-03-25

注記・抄録

博士論文

Recent studies demonstrated that oxidized LDL(Ox-LDL) induces macrophage growth in vitro. The present study was undertaken to elucidate the intracellular signalingpathways for macrophage growth. Ox-LDL initiated a rapid and transient rise in intracellular free calcium ion and inducedactivation of membrane protein kinase C (PKC). Pertussis toxin completely inhibited the Ox-LDL-induced rise in free calcium ion and significantly inhibited macrophage growth by 50%. Moreover, PKC inhibitors calphostin C and H-7 significantly inhibited Ox-LDL-induced macrophage growth by 80%.On the other hand, phospholipase A2-treated acetylated LDL did not induce a rise in calcium but significantly activated PKC and led to significant macrophage growth that was significantly inhibited by calphostin C by 90%. These results suggest thepresence of two intracellular signaling pathways for activation of PKC, a rise in calcium that was mediated by pertussistoxin-sensitive G protein and the internalization of lysophosphatidylcholinethrough the scavenger receptors. These twopathways may play an important role in Ox-LDL-induced macrophage growth.

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各種コード

  • NII論文ID(NAID)
    500000186930
  • NII著者ID(NRID)
    • 8000000187213
  • DOI(NDL)
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000000351244
  • データ提供元
    • 機関リポジトリ
    • NDL ONLINE
    • NDLデジタルコレクション
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