Human hemoglobin vesicles and establishment of their surface modification method ヒトヘモグロビン小胞体とその表面修復法の確立
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著者
書誌事項
- タイトル
-
Human hemoglobin vesicles and establishment of their surface modification method
- タイトル別名
-
ヒトヘモグロビン小胞体とその表面修復法の確立
- 著者名
-
宗, 慶太郎
- 著者別名
-
ソウ, ケイタロウ
- 学位授与大学
-
早稲田大学
- 取得学位
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博士 (工学)
- 学位授与番号
-
甲第1412号
- 学位授与年月日
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2000-03-15
注記・抄録
博士論文
制度:新 ; 文部省報告番号:甲1412号 ; 学位の種類:博士(工学) ; 授与年月日:2000-03-15 ; 早大学位記番号:新2916 ; 理工学図書館請求番号:2405
目次
- Table of Contents / p1 (0004.jp2)
- Preface / (0003.jp2)
- Chapter1:Intermolecular Interaction and Hemoglobin Vesicles / p1 (0007.jp2)
- 1.Introduction / p1 (0007.jp2)
- 2.Intermolecular Interaction and Molecular Assemble / p1 (0007.jp2)
- 3.Assembly of the Amphiphile / p6 (0010.jp2)
- 4.Physicochemical Properties of Phospholipid Vesicles / p11 (0012.jp2)
- 5.Hemoglobin Vesicles and Red Blood Cells / p17 (0015.jp2)
- 6.Surface Modification of the Phospholipid Vesicles / p21 (0017.jp2)
- References and Notes / p25 (0019.jp2)
- Chapter2:Properties and Molecular Assemblies of Glycolipids / p27 (0020.jp2)
- 1.Introduction / p27 (0020.jp2)
- 2.Synthesis of the Glycolipids / p28 (0021.jp2)
- 3.Structure of the glycolipids and their molecular assemblies / p33 (0023.jp2)
- 4.Control the assemblies by the preparation method / p39 (0026.jp2)
- 5.Analysis of the assembling structure by using the molecular dynamic simulation / p44 (0029.jp2)
- 6.Thermodynamical analysis of glycolipid assemblies complexed with concanavalin A / p48 (0031.jp2)
- 7.Summary / p50 (0032.jp2)
- References and Notes / p51 (0032.jp2)
- Chapter3:Surface Modification of the Vesicles with Synthetic Glycolipid / p53 (0033.jp2)
- 1.Introduction / p53 (0033.jp2)
- 2.Surface-modified vesicles with glycolipids / p54 (0034.jp2)
- 3.Stability of the Glyco-vesicles / p55 (0034.jp2)
- 4.Vesicle aggregation by addition of water-soluble polymer / p57 (0035.jp2)
- 5.Aggregation of the vesicles by interaction between saccharide chains and water-soluble polymers / p59 (0036.jp2)
- 6.Vesicle aggregation triggered by interaction between water-soluble polymer and glycolipid / p64 (0039.jp2)
- References and Notes / p68 (0041.jp2)
- Chapter4:Surface Modification of Vesicles with Polyoxyethylene-lipids / p70 (0042.jp2)
- 1.Introduction / p70 (0042.jp2)
- 2.POE-modified vesicles / p70 (0042.jp2)
- 3.Surface modification of the phospholipid vesicles by using the co-assembling phenomenon / p73 (0043.jp2)
- 4.Physicochemical parameters of co-assemble / p78 (0046.jp2)
- 5.Relationship between stability of the vesicles and degree of the POE-modification / p86 (0050.jp2)
- 6.Interbilayer transfer of POE-lipid / p89 (0051.jp2)
- 7.Summary / p92 (0053.jp2)
- References and Notes / p93 (0053.jp2)
- Chapter5:Hydrophobic-Hydrophilic Balance of Multi-acyl lipids and their Intermolecular Interaction / p95 (0054.jp2)
- 1.Introduction / p95 (0054.jp2)
- 2.Syhthesis of the amphiphile with multi-acyl chains / p95 (0054.jp2)
- 3.Relationship between hydrophilic-hydrophobic balance and intermolecular interaction force / p104 (0059.jp2)
- 4.Co-assemmble with phospholipid vesicles / p110 (0062.jp2)
- 5.Summary / p112 (0063.jp2)
- References and Notes / p114 (0064.jp2)
- Chapter6 Stability of the Surface-modified Hemoglobin Vesicles / p116 (0065.jp2)
- 1.Introduction / p116 (0065.jp2)
- 2.Preparation of HbV / p116 (0065.jp2)
- 3.Surface modification of HbV / p118 (0066.jp2)
- 4.Rheological properties / p120 (0067.jp2)
- 5.Stability in long-term storage / p123 (0068.jp2)
- 6.The effect of POE-modification in vivo / p136 (0075.jp2)
- 7.Summary / p138 (0076.jp2)
- References and Notes / p139 (0076.jp2)
- Chapter7 Future Aspect of the Surface-modified Hemoglobin Vesicles as an Oxygen Infusion / p141 (0077.jp2)
- 1.Oxygen Infusion / p141 (0077.jp2)
- 2.Stability of hemoglobin vesicles / p142 (0078.jp2)
- 3.Hemoglobin / p143 (0078.jp2)
- 4.Other application / p144 (0079.jp2)
- References and Notes / p145 (0079.jp2)
- List of Publication / (0080.jp2)
- Acknowledgement / (0080.jp2)
