Function optimization, kinetic reaction analysis and application to bioprocesses of enzymes 酵素の機能最適化、反応動力学解析及びバイオプロセスへの応用

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著者

    • 村上, 義彦 ムラカミ, ヨシヒコ

書誌事項

タイトル

Function optimization, kinetic reaction analysis and application to bioprocesses of enzymes

タイトル別名

酵素の機能最適化、反応動力学解析及びバイオプロセスへの応用

著者名

村上, 義彦

著者別名

ムラカミ, ヨシヒコ

学位授与大学

早稲田大学

取得学位

博士 (工学)

学位授与番号

甲第1413号

学位授与年月日

2000-03-15

注記・抄録

博士論文

制度:新 ; 文部省報告番号:甲1413号 ; 学位の種類:博士(工学) ; 授与年月日:2000-03-15 ; 早大学位記番号:新2917 ; 理工学図書館請求番号:2406

目次

  1. Contents / p1 (0004.jp2)
  2. General Introduction / p1 (0008.jp2)
  3. Backgrounds / p2 (0009.jp2)
  4. The structure cf this thesis / p4 (0010.jp2)
  5. Part I Function,Specificity and Modification of Enzymes / p9 (0013.jp2)
  6. Chapter1 REVIEW:Protease for Biocatalysis / p10 (0014.jp2)
  7. Introduction / p11 (0015.jp2)
  8. General Aspect of Enzymes / p11 (0015.jp2)
  9. External Factors Affecting Protease Activity and Conformation / p20 (0020.jp2)
  10. Conclusions / p24 (0022.jp2)
  11. Rerefences / p24 (0022.jp2)
  12. Chapter2 Effects of Substrates,Organic Solvents and Additives on Enzyme Activity / p29 (0024.jp2)
  13. Introduction / p30 (0025.jp2)
  14. Materials and Method / p31 (0026.jp2)
  15. Results and Discussion / p34 (0027.jp2)
  16. Conclusions / p45 (0033.jp2)
  17. References / p46 (0033.jp2)
  18. Chapter3 Polymer-Enzyme Complex as a Novel Biocatalyst for Nonaqueous Enzymology / p49 (0035.jp2)
  19. Introduction / p50 (0036.jp2)
  20. Materials and Methods / p51 (0037.jp2)
  21. Results and Discussion / p54 (0038.jp2)
  22. Conclusion / p57 (0040.jp2)
  23. References / p58 (0040.jp2)
  24. Part II Analysis of Enzymatic Reactions / p60 (0041.jp2)
  25. Chapter4 REVIEW:Analysis of Enzymatic Reactions / p61 (0042.jp2)
  26. Introduction / p62 (0043.jp2)
  27. Fundamentals / p62 (0043.jp2)
  28. General Aspects of Enzyme-Catalyzed Reactions Kinetics / p64 (0044.jp2)
  29. Basic Methology For Determinations of Kinetic Parameters of Enzyme-Cabalyzed Reactions / p67 (0046.jp2)
  30. Nonlenear Regressions / p70 (0047.jp2)
  31. Conclusions / p71 (0048.jp2)
  32. References / p71 (0048.jp2)
  33. Chapter5 Mathematical Approach to Protease-Catalyzed Peptide Synthesis / p74 (0049.jp2)
  34. Introduction / p75 (0050.jp2)
  35. Materials and Methods / p76 (0051.jp2)
  36. Results and Discussion / p77 (0051.jp2)
  37. Conclusions / p90 (0058.jp2)
  38. Nomenclatures / p90 (0058.jp2)
  39. References / p91 (0058.jp2)
  40. Chapter6 Novel Method for Analysis of Enzymatic Reactions:Evaluation of Kinetic Parameters / p93 (0059.jp2)
  41. Introduction / p94 (0060.jp2)
  42. Theoretical Approaches to the Protease-Catalyzed Peptide Synthesis to Obtain Kinetic Parameters / p95 (0061.jp2)
  43. Materials and Methods / p98 (0062.jp2)
  44. Results and Discussion / p99 (0063.jp2)
  45. CONCLUTIONS / p108 (0067.jp2)
  46. NOMENCLATURE / p108 (0067.jp2)
  47. REFERENCES / p109 (0068.jp2)
  48. Part III Development of Processes of Enzymatic Peptide Productions / p111 (0069.jp2)
  49. Chapter7 REVIEW:Enzymatic Synthesis of Biologically Active Peptides / p112 (0070.jp2)
  50. INTRODUCTION / p113 (0071.jp2)
  51. General Aspects of Peptide Synthesis:Chemical,Recombinant DNA Versus Enzymatic Conversion / p114 (0072.jp2)
  52. Strategies to Equiribrium-and Kinetically-Controlled Enzymatic Synthesis of Biologically Active Peptides to Obtain Them in High Yields / p116 (0073.jp2)
  53. Selection of Enzymes,Substrates and Reaction Conditions / p119 (0074.jp2)
  54. Modifications of Enzymes / p123 (0076.jp2)
  55. Reaction Media / p132 (0081.jp2)
  56. Conclusions / p138 (0084.jp2)
  57. References / p139 (0084.jp2)
  58. Chapter8 Extractive Synthesis of Peptides in Aqueous/Organic Biphasic Medium / p152 (0091.jp2)
  59. Introduction / p153 (0092.jp2)
  60. Materials and Methods / p155 (0093.jp2)
  61. Results and Discussion / p160 (0096.jp2)
  62. Conclusions / p187 (0109.jp2)
  63. Nomenclature / p189 (0110.jp2)
  64. References / p189 (0110.jp2)
  65. Chapter9 Novel Process for Peptide Synthesis Catalyzed by Modified Enzymes in Organic Media. / p192 (0112.jp2)
  66. Introduction / p193 (0113.jp2)
  67. Materials and Methods / p196 (0115.jp2)
  68. Results and Discussion / p198 (0116.jp2)
  69. Conclusions / p209 (0121.jp2)
  70. Nomenclature / p210 (0122.jp2)
  71. References / p210 (0122.jp2)
  72. Chapter10 Enzymatic Protein Hydrolysis in Aqueous and Organic Two-Phase Systems / p213 (0123.jp2)
  73. Introduction / p214 (0124.jp2)
  74. Materials and Methods / p216 (0125.jp2)
  75. Results and Discussion / p219 (0127.jp2)
  76. Conclusions / p228 (0131.jp2)
  77. References / p229 (0132.jp2)
  78. General Conclusions / p231 (0133.jp2)
  79. Acknowledgements / p237 (0137.jp2)
  80. Appendix / p240 (0139.jp2)
  81. Appendix1 Derivation of Equations in Chapters5 and 6 / p241 (0140.jp2)
  82. Appendix2 Abstract,Curriculum Vitae and Publication Lists / p253 (0147.jp2)
  83. Abstract / p254 (0148.jp2)
  84. Curriculum Vitae / p256 (0149.jp2)
  85. Publication List Related to This Thesis / p257 (0150.jp2)
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各種コード

  • NII論文ID(NAID)
    500000188466
  • NII著者ID(NRID)
    • 8000000188749
  • DOI(NDL)
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000000352780
  • データ提供元
    • 機関リポジトリ
    • NDL ONLINE
    • NDLデジタルコレクション

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