In vitro and in vivo evaluation of the role of complement in the clearance of liposomes

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著者

    • Tran, Minh Huong トラン, ミンフン

書誌事項

タイトル

In vitro and in vivo evaluation of the role of complement in the clearance of liposomes

著者名

Tran, Minh Huong

著者別名

トラン, ミンフン

学位授与大学

徳島大学

取得学位

博士 (薬学)

学位授与番号

甲第1083号

学位授与年月日

2000-03-26

注記・抄録

博士論文

目次

  1. 論文目録 / (0003.jp2)
  2. 論文内容要旨 / (0004.jp2)
  3. Contents / (0008.jp2)
  4. Chapter1 Introduction / p1 (0010.jp2)
  5. References / p3 (0011.jp2)
  6. Chapter2 Role of complement in the clearance of liposomes in rats / p7 (0013.jp2)
  7. Section1 Complement-induced degradation of liposomes in rat serum / p8 (0014.jp2)
  8. Section2 Pharmacokinetics of liposomes in rats / p9 (0014.jp2)
  9. Section3 Correlation between complement-induced degradation in vitro and the in vivo hepatic uptake clearance / p13 (0016.jp2)
  10. Section4 Factors influencing the activation of complement by liposomes / p15 (0017.jp2)
  11. Section5 Conclusion / p19 (0019.jp2)
  12. Section6 Experiments / p20 (0020.jp2)
  13. References / p23 (0021.jp2)
  14. Chapter3 Uptake of liposomes by rat peritoneal macrophages / p26 (0023.jp2)
  15. Section1 Effects of size and cholesterol content on liposome uptake / p27 (0023.jp2)
  16. Section2 Relationship between in vivo and in vitro uptake / p33 (0026.jp2)
  17. Section3 Conclusion / p34 (0027.jp2)
  18. Section4 Experiments / p34 (0027.jp2)
  19. References / p37 (0028.jp2)
  20. Chapter4 Role of complement in the clearance of liposomes in guinea pigs.Model of complement-deficient animals for in vivo study / p40 (0030.jp2)
  21. Section1 Degradation of liposomes in serum / p41 (0030.jp2)
  22. Section2 Pharmacokinetics of liposomes in guinea pigs / p42 (0031.jp2)
  23. Section3 Model of complement-defficient animals for in vivo study / p45 (0032.jp2)
  24. Section4 Conclusion / p52 (0036.jp2)
  25. Section5 Experiments / p53 (0036.jp2)
  26. References / p55 (0037.jp2)
  27. Chapter5 Evaluation of the third complement component bound to liposomes / p59 (0039.jp2)
  28. Section1 Level of the third complement component bound to liposome in rats and guinea pigs and the effect of the treatment by K76COOH / p60 (0040.jp2)
  29. Section2 Relationship between the amount of the third complement component bound to liposomes and biological fate of liposomes / p67 (0043.jp2)
  30. Section3 Conclusion / p73 (0046.jp2)
  31. Section4 Experiments / p73 (0046.jp2)
  32. References / p76 (0048.jp2)
  33. Chapter6 Summary and concluding remarks / p80 (0050.jp2)
  34. Acknowledgements / p84 (0052.jp2)
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各種コード

  • NII論文ID(NAID)
    500000188626
  • NII著者ID(NRID)
    • 8000000188909
  • DOI(NDL)
  • NDL書誌ID
    • 000000352940
  • データ提供元
    • NDL ONLINE
    • NDLデジタルコレクション
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