Study on drug-DNA minor groove interactions and DNA supercoiling by using hydrostatic pressure as a perturbation agent
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著者
書誌事項
- タイトル
-
Study on drug-DNA minor groove interactions and DNA supercoiling by using hydrostatic pressure as a perturbation agent
- 著者名
-
唐, 国慶
- 著者別名
-
トウ, コクケイ
- 学位授与大学
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京都工芸繊維大学
- 取得学位
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博士 (学術)
- 学位授与番号
-
甲第187号
- 学位授与年月日
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1999-03-25
注記・抄録
博士論文
目次
- Content / (0003.jp2)
- Chapter1:General Introduction / p1 (0004.jp2)
- §1.1 The Minor groove Binding of drugs with DNA / p1 (0004.jp2)
- §1.2 DNA Supercoiling / p4 (0006.jp2)
- §1.3 High pressure study related to structure and drug-interactions of nucleic acids / p7 (0007.jp2)
- §1.4 Scope of present work / p8 (0008.jp2)
- References / p10 (0009.jp2)
- Chapter2:DNA Minor Groove Binding Studied by Restriction Endonuclease Protection Assay under Hydrostatic Pressure / p12 (0010.jp2)
- §2.1 Introduction / p12 (0010.jp2)
- §2.2 Materials and Methods / p13 (0010.jp2)
- §2.3 Results / p16 (0012.jp2)
- §2.4 Discussions / p24 (0016.jp2)
- References / p27 (0017.jp2)
- Chapter3:DNA Minor Groove Binding Studied by Fluorometric Titration under Pressure:Example of Hoechst 33258 / p29 (0018.jp2)
- §3.1 Introduction / p29 (0018.jp2)
- §3.2 Materials and Methods / p30 (0019.jp2)
- §3.3 Results / p32 (0020.jp2)
- §3.4 Discussions / p39 (0023.jp2)
- References / p44 (0026.jp2)
- Chapter4:Environment-Induced Fluorescence Spectral Shifts of Hoechst 33258 Bound to DNA: Implications for DNA Conformational Changes / p46 (0027.jp2)
- §4.1 Introduction / p46 (0027.jp2)
- §4.2 Materials and Methods / p47 (0027.jp2)
- §4.3 Results / p48 (0028.jp2)
- §4.4 Discussions / p59 (0033.jp2)
- References / p64 (0036.jp2)
- Chapter5:Characterization of in vitro Pressure Effects on Winding of the DNA Helix / p66 (0037.jp2)
- §5.1 Introduction / p66 (0037.jp2)
- §5.2 Materials and Methods / p67 (0037.jp2)
- §5.3 Results and Discussions / p71 (0039.jp2)
- References / p85 (0046.jp2)
- Chapter6:Summary / p87 (0047.jp2)
- Abbreviation / p91 (0049.jp2)
- List of Publications / p92 (0050.jp2)
- Acknowledgement / p93 (0050.jp2)