Studies concerning the biosynthesis and metabolism of endothelium-derived relaxing factor (nitric oxide) and endothelium-derived contracting factor (endothelin-1) in the diabetic state

Access this Article

Title: Studies concerning the biosynthesis and metabolism of endothelium-derived relaxing factor (nitric oxide) and endothelium-derived contracting factor (endothelin-1) in the diabetic state

博士論文

Contents / (0003.jp2)
General introduction / p1 (0004.jp2)
Chapter 1 / p7 (0007.jp2)
A comparative study on the rat aorta and mesenteric arterial bed o the possible role of nitric oxide in the desensitization of the vasoconstrictorresponse to an α₁-adrenoceptor agonist / p7 (0007.jp2)
1-1)Introduction / p8 (0008.jp2)
1-2)Methods / p9 (0009.jp2)
1-3)Results / p13 (0011.jp2)
1-4)Discussion / p24 (0016.jp2)
Chapter 2 / p28 (0018.jp2)
Elevated plasma endothelin-1 level in streptozotocin-induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin-1 / p28 (0018.jp2)
2-1)Introduction / p29 (0019.jp2)
2-2)Methods / p30 (0020.jp2)
2-3)Results / p33 (0021.jp2)
2-4)Discussion / p44 (0027.jp2)
Chapter 3 / p47 (0028.jp2)
Time-course changes in plasma endothelin-1 and its effects on the mesenteric arterial bed in streptozotocin-induced diabetic rats / p47 (0028.jp2)
3-1)Introduction / p48 (0029.jp2)
3-2)Methods / p49 (0030.jp2)
3-3)Results / p53 (0032.jp2)
3-4)Discussion / p61 (0036.jp2)
Chapter 4 / p65 (0038.jp2)
Possible modulation by endothelin-1,nitric oxide,prostaglandin I₂ and thromboxane A₂ of vasoconstriction induced by an α agonist in mesenteric arterial bed from diabetic rats / p65 (0038.jp2)
4-1)Introduction / p66 (0039.jp2)
4-2)Methods / p67 (0040.jp2)
4-3)Results / p71 (0042.jp2)
4-4)Discussion / p82 (0047.jp2)
Conclusion / p87 (0050.jp2)
Acknowledgments / p89 (0051.jp2)
References / p90 (0051.jp2)