Effects of tributyltin and 2,4,5-trichlorophenoxyacetic acid on apoptosis and differentiation in PC12 cells PC12細胞のアポトーシスおよび分化に対するトリブチルスズおよび2,4,5-トリクロロフェノキシ酢酸の影響

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著者

    • 山ノ下, 理 ヤマノシタ, オサム

書誌事項

タイトル

Effects of tributyltin and 2,4,5-trichlorophenoxyacetic acid on apoptosis and differentiation in PC12 cells

タイトル別名

PC12細胞のアポトーシスおよび分化に対するトリブチルスズおよび2,4,5-トリクロロフェノキシ酢酸の影響

著者名

山ノ下, 理

著者別名

ヤマノシタ, オサム

学位授与大学

北海道大学

取得学位

博士 (環境科学)

学位授与番号

甲第5238号

学位授与年月日

2000-03-24

注記・抄録

博士論文

目次

  1. CONTENTS / (0003.jp2)
  2. SUMMARY / p1 (0004.jp2)
  3. INTRODUCTION / p4 (0007.jp2)
  4. MATERIALS AND METHODS / p7 (0010.jp2)
  5. Materials / p7 (0010.jp2)
  6. Incubation of PC12 cells at several concentrations of TBT and 2,4,5-T / p8 (0011.jp2)
  7. Enzymed linked-immunosorbent assays (ELISA) of TFIIH, p36,SP1 BAD,BAX,BCL-2 and p53 in PC12 cells / p8 (0011.jp2)
  8. Detection of DNA fragmentation in PC12 cells by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method / p9 (0012.jp2)
  9. Microscopic detection of DNA fragmentation in PC12 cells by the TUNEL method / p10 (0013.jp2)
  10. Effects of serum deprivation and disrupter stress on cell viability / p11 (0014.jp2)
  11. Nuclei DNA isolation and fragmentation assay / p11 (0014.jp2)
  12. Tin concentration in nuclei / p12 (0015.jp2)
  13. Effects of TBT and 2,4,5-T in PC12 cells, which respond to NGF / p12 (0015.jp2)
  14. Statistical analysis / p13 (0016.jp2)
  15. RESULTS / p14 (0017.jp2)
  16. DNA fragmentation levels of several concentrations of TBT and 2,4,5-T / p14 (0017.jp2)
  17. Microscopic detection of DNA damage / p14 (0017.jp2)
  18. Cell viability / p15 (0018.jp2)
  19. Contents of BAD, BAX, p53 and BCL-2 in PC12 / p15 (0018.jp2)
  20. Contents of TFIIH in PC12 by ELISA / p16 (0019.jp2)
  21. Tin concentration / p16 (0019.jp2)
  22. DNA isolation and fragmentation assay / p17 (0020.jp2)
  23. Effects of TBT and 2,4,5-T on NGF-induced differentiation of PC12 cells / p17 (0020.jp2)
  24. DISCUSSION / p19 (0022.jp2)
  25. ACKNOWLEDGMENTS / p23 (0026.jp2)
  26. REFERENCES / p24 (0027.jp2)
  27. FIGURE LEGENDS / p30 (0033.jp2)
  28. FIGURES and TABLE / (0036.jp2)
  29. Direct Visualization of Copper-Metallothionein in LEC Rat Kidneys: Application of Autofluorescence Signal of Copper-Thiolate Cluster / p865 (0052.jp2)
  30. Visualization of yellowish-orange luminescence from cuprous metallothioneins in liver of Long-Evans Cinnamon rat / p150 (0061.jp2)
  31. Histochemical Characterization of Silver-induced Metallothionein in Kidney of Rat / p1 (0070.jp2)
  32. COPPER METABOLISM IN THE RODENT KIDNEYS / p1 (0090.jp2)
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各種コード

  • NII論文ID(NAID)
    500000189681
  • NII著者ID(NRID)
    • 8000000189964
  • DOI(NDL)
  • NDL書誌ID
    • 000000353995
  • データ提供元
    • NDL ONLINE
    • NDLデジタルコレクション
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