Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat スポーツ肥大心と病的肥大心では種々の遺伝子の発現様式が異なる : ラットでの検討

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著者

    • 家光, 素行 イエミツ, モトユキ

書誌事項

タイトル

Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat

タイトル別名

スポーツ肥大心と病的肥大心では種々の遺伝子の発現様式が異なる : ラットでの検討

著者名

家光, 素行

著者別名

イエミツ, モトユキ

学位授与大学

筑波大学

取得学位

博士 (医学)

学位授与番号

甲第3195号

学位授与年月日

2003-03-25

注記・抄録

博士論文

Intence exercise causes decrease in expression of both endothelial NO synthase and tissue NO_X level in hearts. Am J Physiol Regulatory Integrative Comp Physiol 279:R951-R959, 2000. -Cardiac myocytes produce nitric oxide (NO). We studied the effects of intense exercise on the expression of NO synthase (NOS) and the tissue level of nitrite (NO^-_2)/nitrate (NO^-_3) (i.e.,NOx), which are stable end products of NO in the heart. Rats ran on a treadmill for 45min. Immediately after this exercise, the heart was quickly removed. Control rats remained at rest during the same 45-min period. The mRNA level of endothelial NOS (eNOS) in the heart was markedly lower in the exercised rats than in the control rats. Western blot analysis confirmed downregulation of eNOS protein in the heart after exercise. Tissue NOx level in the heart was singnificantly lower in the exercised rats than in the control rats. The present study revealed for the first time that prosuction of NO in the heart is decreased by intense exercise. Because NO attenuates positive inotropic and chronotropic responses to β_1-adrenergic stimulation in the heart, the decrease in cardiac production of NO by intense exercise may contribute to the acceleration of increase in myocardial contractility and heart rate during intense exercise.

Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 3195, 2003.3.25

Includes bibliographical references

Joint authors: Takashi Miyauchi ... et al

Offprint. Originally published in: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, v. 281, pp. R2029-R2036, 2001

Includes supplementary treatises

Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat ~ Iemitsu,M/Miyauchi,T/Maeda,S/Sakai,S/Kobayashi,T/Fujii,N/Miyazaki,H/Matsuda,M/Yamaguchi,I

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各種コード

  • NII論文ID(NAID)
    500000242562
  • NII著者ID(NRID)
    • 8000000243175
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000004277954
  • データ提供元
    • 機関リポジトリ
    • NDL ONLINE
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