Impaired proliferative response of Vα24 NKT cells from cancer patients against α-galactosylceramide 担癌患者NKT細胞のα-Galactosylceramideに対する増殖能力の低下

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著者

    • 柳澤, 和彦 ヤナギサワ, カズヒコ

書誌事項

タイトル

Impaired proliferative response of Vα24 NKT cells from cancer patients against α-galactosylceramide

タイトル別名

担癌患者NKT細胞のα-Galactosylceramideに対する増殖能力の低下

著者名

柳澤, 和彦

著者別名

ヤナギサワ, カズヒコ

学位授与大学

筑波大学

取得学位

博士 (医学)

学位授与番号

甲第3204号

学位授与年月日

2003-03-25

注記・抄録

博士論文

Human invariant Vα24^+NKT cells are a relatively new subpopulation of lymphocytes. It has been reported that Vα24 NKT cells are significantly involved in some human diseases. We have evaluated the number and function of Vα24 NKT cells in both healthy volunteers and cancer patients. In this study we found that Vα24 NKT cells in unfractionated PBMCs obtained from cancer patients did not respond efficiently to α-galactosylceramide(α-GalCer) in vitro. Thus, their proportion after stimulation with α-GalCer was smaller than that found in healthy volunteers. However, the cancer patients' Vα24 NKT cells retained cytotoxic activety against malignant target cells, and they could efficiently proliferate to α-GalCer when fractionated by sorting. Furthermore, we found that addition of G-CSF to the culture could restore the low proliferative response of Vα24 NKT cells from cancer patients. These results suggest that some functions of NKT cells in cancer patients are impaired, and this observation carries significant implications for immunotherapy-based cancer treatments.

Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 3204, 2003.3.25

Includes bibliographical references

Joint authors: Ken-ichiro Seino ... et al

Offprint. Originally published in: The Journal of Immunology, v. 168, pp. 6494-6499, 2002

Includes supplementary treatises

Impaired Proliferative Response of Vα24 NKT Cells from Cancer Patients Against α-Galactosylceramide ~ 柳澤,和彦

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各種コード

  • NII論文ID(NAID)
    500000242568
  • NII著者ID(NRID)
    • 8000000243181
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000004277978
  • データ提供元
    • 機関リポジトリ
    • NDL ONLINE
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