A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress 温熱ストレスによる骨格筋肥大におけるNF-κBとHSP72の役割
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著者
書誌事項
- タイトル
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A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress
- タイトル別名
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温熱ストレスによる骨格筋肥大におけるNF-κBとHSP72の役割
- 著者名
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大野, 善隆
- 著者別名
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オオノ, ヨシタカ
- 学位授与大学
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名古屋大学
- 取得学位
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博士 (リハビリテーション療法学)
- 学位授与番号
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甲第9070号
- 学位授与年月日
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2011-03-25
注記・抄録
博士論文
Effects of heat stress on phosphorylated nuclear factor-κB (phospho-NF-κB) and tumor necrosis factor α (TNFα) contents in skeletal muscles were studied. Male Wistar rats (7-week-old) were randomly assigned to control and heat-stressed groups. Rats in heat-stressed group were exposed to heat stress (42°C for 60 min) in an incubator without anesthesia. Soleus muscles were dissected and weighted 1, 3, and 7 days after the heat exposure. Significant increases in the wet weight and protein content of soleus were observed 7 days following the exposure (p < 0.05). Heat stress also induced the up-regulation of heat shock protein 72 (HSP72), IκBα (inhibitor of NF-κB) and the increase in the relative population of Pax7-positive satellite cells to total muscle nuclei before the increase in muscle mass. The content levels of phospho-NF-κB and TNFα were significantly decreased 1 and 3 days after heat stress, respectively (p < 0.05). A negative correlation between HSP72 and phospho-NF-κB contents was observed 1 day after the heat exposure. These observations suggest that the decrease in NF-κB signaling may play a part of a role in heat stress-associated muscle hypertrophy.
名古屋大学博士学位論文 学位の種類:博士(リハビリテーション療法学) (課程) 学位授与年月日:平成23年3月25日