Allelic Loss Analysis of Lymphomas Induced in Fas-Heterozygous Deficient Mice

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  • OGAWA Shoji
    Department of Veterinary Sciences, College of Agriculture, Osaka Prefecture University
  • HONG Doo-Pyo
    Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University
  • MORI Nobuko
    Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University Research Institute for Advanced Science and Technology, Osaka Prefecture University
  • UMESAKO Seiichi
    Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University
  • SONG Chang-Woo
    Korea Research Institute of Chemical Technology
  • OKUMOTO Masaaki
    Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University Research Institute for Advanced Science and Technology, Osaka Prefecture University

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Mutations of Fas (CD95/Apo-1) gene have been reported in various malignancies and therefore the Fas gene has been considered to be a tumor suppressor gene. To examine an involvement of Fas gene as a tumor suppressor gene in radiation lymphomagenesis, we examined the loss of heterozygosity (LOH) in lymphomas from (MSM/Ms x MRL-MpJ/Fas lpr) F1 and (BALB/cHeA × MRL-MpJ/Fas lpr) F1 hybrid mice. Lymphoma development by X-irradiation was efficiently observed in both F1 hybrids. Frequent LOH was found on chromosomes 12 and 4 in the tumors from both F1 mice, but no allelic loss on chromosome 19 containing Fas locus was found, and no wild-type allele of the Fas gene was lost in 51 lymphomas. Therefore, the putative tumor-suppressor gene regions responsible for lymphomagenesis might not considerably differ due to the Fas gene status.<br>

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