Angiotensin Converting Enzyme Genotype Influences the Response to the Angiotensin II Receptor Antagonist Losartan in Patients with Hypertension
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- NAKAMURA Yasuyuki
- Division of Cardiology, Department of Medicine, Shiga University of Medical Science
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- TAMAKI Shinji
- Division of Cardiology, Department of Medicine, Shiga University of Medical Science
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- UCHIDA Yasukazu
- Moriyama Public Hospital
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- OHMICHI Nobuyuki
- Social Insurance Shiga Hospital
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- YAMAOKA Osamu
- Social Insurance Shiga Hospital
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- MIYAUCHI Nobuo
- Shigaraki National Hospital
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- FUKUHARA Takehisa
- Division of Cardiology, Department of Medicine, Shiga University of Medical Science
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- SAYAMA Harumi
- Hino Memorial Hospital
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- YAMADA Tetsuhiro
- Division of Cardiology, Department of Medicine, Shiga University of Medical Science
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- MATSUO Shinro
- Division of Cardiology, Department of Medicine, Shiga University of Medical Science
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- YAMADA Yutaka
- Vories Memorial Hospital
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Abstract
To examine whether the response to the angiotensin II receptor antagonist losartan varies depending on the angiotensin converting enzyme (ACE) genotype, we prospectively studied the effect of losartan in 42 hypertensive patients (20 men, 22 women; mean age: 60.4 years). After a 4-week observation period, losartan was administered at 50 mg/day and blood pressure was measured every 2 to 4 weeks for 12 weeks. Among the 42 patients, 19, 11, and 12, respectively, had the II, ID, and DD ACE genotypes. The baseline plasma ACE activity in patients with the ID or DD genotype was significantly higher than that in patients with the II genotype (13.8±4.2 vs. 9.6±2.3 IU/l; p =0.0002). However, age, gender, baseline systolic and diastolic blood pressure (SBP/DBP), and body mass index (BMI) were not different among the groups. After 12 weeks of treatment with losartan alone, DBP in the ID+DD group was significantly higher than that in the II group (85.0±9.0 vs. 77.8±9.6 mmHg, p =0.018), while the percent reduction in DBP in the ID+DD group was significantly smaller than that in the II group (7.9±8.8 vs. 14.3±10.1%, p =0.035). Multiple regression analysis showed that the significant predictors of the DBP at 12 weeks were age (p =0.030), ACE genotype (p =0.029) and baseline DBP (p =0.0001). The ACE genotype may be a determinant of the response to losartan in hypertensive patients. (Hypertens Res 2004; 27: 137-140)
Journal
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- Hypertension Research
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Hypertension Research 27 (3), 137-140, 2004
The Japanese Society of Hypertension
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Details 詳細情報について
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- CRID
- 1390282679698150912
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- NII Article ID
- 130004437148
- 50000460251
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- NII Book ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD2cXkslOlu7g%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 15080371
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed