Steryl Glucoside is a Lipid Mediator in Stress-responsive Signal Transduction.
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- Kunimoto Shohko
- Department of Biology, Faculty of Science, Ochanomizu University
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- Murofushi Wataru
- Department of Biology, Faculty of Science, Ochanomizu University Tsukuba University School of Medicine
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- Kai Hirofumi
- Department of Pharmaceutical Sciences, Graduate School of Kumamoto University
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- Ishida Yoko
- Department of Biology, Faculty of Science, Ochanomizu University
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- Uchiyama Ayako
- Department of Biology, Faculty of Science, Ochanomizu University
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- Kobayashi Tetsuyuki
- Department of Biology, Faculty of Science, Ochanomizu University
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- Kobayashi Susumu
- Faculty of Pharmaceutical Sciences, Science University of Tokyo
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- Murofushi Hiromu
- Department of Biophysics and Biochemistry, Graduate School of Tokyo University
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- Murakami-Murofushi Kimiko
- Department of Biology, Faculty of Science, Ochanomizu University
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Abstract
We previously reported that steryl glucoside (SG) is rapidly induced in cells from molds to humans by exposure to environmental stress (Murakami-Murofushi et al. (1997) J. Biol. Chem., 272, 486-489, Kunimoto et al. (2000) Cell Stress & Chaperones, 5, 3-7), and in mold cells SG production is followed by activation of a certain protein kinase and induction of heat shock proteins (HSP) (Maruya et al. (1997) Cell Struct. Funct., 21, 533-538). To determine the biological significance of SG in stress responsive signal transduction, we added SG to the culture of human fibroblasts and examined its effect on HSP induction. We demonstrated a rapid activation of heat shock transcription factor 1 (HSF1) to bind to heat shock element (HSE) and induction of heat shock protein 70 (HSP70) in fibroblast cells by exposure to exogenously added human major SG, cholesteryl glucoside (CG). In addition, enzyme activity to form CG from cholesterol and UDP-glucose was detected in the homogenate of fibroblast cells. These results strongly suggest that CG acts as a mediator in the early stage of stress responsive signal transduction.<br>
Journal
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- Cell Structure and Function
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Cell Structure and Function 27 (3), 157-162, 2002
Japan Society for Cell Biology
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Details 詳細情報について
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- CRID
- 1390282679671478656
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- NII Article ID
- 50000617080
- 130004137445
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- NII Book ID
- AA0060007X
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- COI
- 1:CAS:528:DC%2BD38Xns1aht78%3D
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- ISSN
- 13473700
- 03867196
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- NDL BIB ID
- 6291513
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- PubMed
- 12207046
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed