Severe Abdominal Pain Associated with Allergic Reaction to Nafamostat Mesilate in a Chronic Hemodialysis Patient.

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  • YAMAZATO Masanobu
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • MANO Rieko
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • OSHIRO-CHINEN Saori
    Dialysis Unit, University of the Ryukyus, School of Medicine
  • TOMIYAMA Nozomi
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • SAKIMA Atsushi
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • ISHIDA Akio
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • TANA Takeshi
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • TOZAWA Masahiko
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • MURATANI Hiromi
    The Third Department of Internal Medicine, University of the Ryukyus, School of Medicine
  • ISEKI Kunitoshi
    Dialysis Unit, University of the Ryukyus, School of Medicine
  • TAKISHITA Shuichi
    Dialysis Unit, University of the Ryukyus, School of Medicine

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A 33-year-old woman was referred from an outside dialysis clinic to our hospital because of severe abdominal pain during hemodialysis. She had been on chronic hemodialysis for the past 11 years due to chronic glomerulonephritis. Nafamostat mesilate was used as an anticoagulant for hemodialysis, because it was during her menstrual period with hypermenorrhea. On admission, she had no abdominal pain or gynecological abnormalities. On the second day, she had similar abdominal pain during hemodialysis with nafamostat mesilate in our dialysis unit. The abdominal pain disappeared within 60 minutes after discontinuing the hemodialysis. We re-started dialysis using heparin instead of nafamostat mesilate and she had no symptoms. The titer of total immunoglobulin E was high. The drug lymphocyte stimulation test was positive for nafamostat mesilate and antigen specific immunoglobulin E to nafamostat mesilate was highly positive in her blood. Although an allergic reaction to nafamostat mesilate is a rare complication, it should be one of the differential diagnoses of abdominal pain occurring during hemodialysis.<br>(Internal Medicine 41: 864-866, 2002)

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  • Internal Medicine

    Internal Medicine 41 (10), 864-866, 2002

    一般社団法人 日本内科学会

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