Increased Urinary Levels of Pentosidine, Pyrraline and Acrolein Adduct in Type 2 Diabetes.

• DAIMON MAKOTO

  Third Department of Internal Medicine, Yamagata University School of Medicine

• SUGIYAMA KAZUHIKO

  Division of Internal Medicine, Yamagata Saisei Hospital

• KAMEDA WATARU

  Third Department of Internal Medicine, Yamagata University School of Medicine

• SAITOH TAMOTSU

  Third Department of Internal Medicine, Yamagata University School of Medicine

• OIZUMI TOSHIHIDE

  Third Department of Internal Medicine, Yamagata University School of Medicine

• HIRATA AKIHIKO

  Department of Laboratory Medicine, Yamagata University School of Medicine

• YAMAGUCHI HIROSHI

  Third Department of Internal Medicine, Yamagata University School of Medicine

• OHNUMA HIROSHI

  Third Department of Internal Medicine, Yamagata University School of Medicine

• IGARASHI MASAHIKO

  Department of Laboratory Medicine, Yamagata University School of Medicine

• KATO TAKEO

  Third Department of Internal Medicine, Yamagata University School of Medicine

Abstract

This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the outpatient clinic of our university hospital were compared with those of age- and sex-matched non-diabetic subjects(n = 50). The correlation of these urinary levels with the glycemic control and the clinical traits were examined. Furthermore, the influence of smoking habit on the levels of acrolein adduct was examined. Urinary levels of pentosidine, pyrraline and acrolein adduct were all significantly (p<0.001) higher in the DM group than in the non-DM group (pentosidine(log(pmol/mgCr)), 1.579 ± 0.147 vs 1.427 ± 0.142; pyrraline (log(nmol/mgCr)), 0.888 ± 0.402 vs 0.581 ± 0.336; acrolein adduct (log(nmol/mgCr)), 2.316 ± 0.221 vs 2.051 ± 0.201). Glycemic control parameters, such as fasting plasma glucose (FPG) and HbAlc, were significantly correlated with these urinary levels. Age was correlated with the urinary levels of pentosidine but not with those of pyrraline and acrolein adduct. The urinary albumin excretion rate did not correlate with any of these urinary levels. The levels of acrolein adduct were higher in the subjects with smoking habit than in those without the habit in the DM group as well as in the non-DM group (DM, 2.391 ± 0.230 and 2.212 ± 0.190, p = 0.0004; Non-DM, 2.120 ± 0.171 and 1.993 ± 0.206, p = 0.0503). The urinary levels of pentosidine, pyrraline and acrolein adduct were increased in DM and were significantly correlated with glycemic control levels. In addition, smoking habit seems to increase the urinary levels of acrolein adduct.

Journal

• Endocrine Journal

  Endocrine Journal 50 (1), 61-67, 2003

  The Japan Endocrine Society

Keywords

• Pentosidine
• Pyrraline
• Acrolein adduct
• Urinary excretion
• Smoking

Details

• CRID: 1390282681274990464
• NII Article ID: 130004443013
• NII Article ID: 50000749910
• NII Book ID: AA10901436
• DOI: 10.1507/endocrj.50.61
• COI: 1:CAS:528:DC%2BD3sXjtFelsLw%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 12733710
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/50/1/50_1_61/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003171140
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed